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Staff at EMBL


Dr. Philip Avner

Head of Outstation and Senior Scientist
Avner Group

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: send a mail


PhD in yeast genetics, University of Warwick.
CNRS Director of Research.
Head of the Mouse Molecular Genetics Unit at the Institut Pasteur 1990-2011.
Head of the Developmental Biology Department at the Institut Pasteur 2006-2011.
Head of EMBL Monterotondo since 2012.


Total: 39 publication(s)


Merzouk S, Deuve JL, Dubois A, Navarro P, Avner P, Morey C. (2014)
Lineage-specific regulation of imprinted X inactivation in extraembryonic endoderm stem cells
Epigenetics Chromatin 7:11. doi:10.1186/1756-8935-7-11
Europe PMC | doi

Dubois A, Deuve JL, Navarro P, Merzouk S, Pichard S, Commere PH, Louise A, Arnaud D, Avner P, Morey C. (2014)
Spontaneous reactivation of clusters of X-linked genes is associated with the plasticity of X-inactivation in mouse trophoblast stem cells
Stem Cells 32(2):377-390. doi:10.1002/stem.1557
Europe PMC | doi


Attia M, Rachez C, Avner P, Rogner UC. (2013)
Nucleosome assembly proteins and their interacting proteins in neuronal differentiation
Arch. Biochem. Biophys. 534(1-2):20-26. doi:10.1016/
Europe PMC | doi


Morey C, Avner P. (2011)
The demoiselle of X-inactivation: 50 years old and as trendy and mesmerising as ever
PLoS Genet. 7(7):e1002212. doi:10.1371/journal.pgen.1002212
Europe PMC | doi

Clerc P, Avner P. (2011)
New lessons from random X-chromosome inactivation in the mouse
J. Mol. Biol. 409(1):62-69. doi:10.1016/j.jmb.2011.02.022
Europe PMC | doi

Attia M, Förster A, Rachez C, Freemont P, Avner P, Rogner UC. (2011)
Interaction between nucleosome assembly protein 1-like family members
J. Mol. Biol. 407(5):647-660. doi:10.1016/j.jmb.2011.02.016
Europe PMC | doi

Chureau C, Chantalat S, Romito A, Galvani A, Duret L, Avner P, Rougeulle C. (2011)
Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region
Hum. Mol. Genet. 20(4):705-718. doi:10.1093/hmg/ddq516
Europe PMC | doi

Deuve JL, Avner P. (2011)
The coupling of X-chromosome inactivation to pluripotency
Annu. Rev. Cell Dev. Biol. 27:611-629. doi:10.1146/annurev-cellbio-092910-154020
Europe PMC | doi


Navarro P, Oldfield A, Legoupi J, Festuccia N, Dubois A, Attia M, Schoorlemmer J, Rougeulle C, Chambers I, Avner P. (2010)
Molecular coupling of Tsix regulation and pluripotency
Nature 468(7322):457-460. doi:10.1038/nature09496
Europe PMC | doi

He CX, Prevot N, Boitard C, Avner P, Rogner UC. (2010)
Inhibition of type 1 diabetes by upregulation of the circadian rhythm-related aryl hydrocarbon receptor nuclear translocator-like 2
Immunogenetics 62(9):585-592. doi:10.1007/s00251-010-0467-7
Europe PMC | doi

Navarro P, Avner P. (2010)
An embryonic story: analysis of the gene regulative network controlling Xist expression in mouse embryonic stem cells
Bioessays 32(7):581-588. doi:10.1002/bies.201090024
Europe PMC | doi

Chow JC, Ciaudo C, Fazzari MJ, Mise N, Servant N, Glass JL, Attreed M, Avner P, Wutz A, Barillot E, Greally JM, Voinnet O, Heard E. (2010)
LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation
Cell 141(6):956-969. doi:10.1016/j.cell.2010.04.042
Europe PMC | doi

Maenner S, Blaud M, Fouillen L, Savoye A, Marchand V, Dubois A, Sanglier-Cianférani S, Van Dorsselaer A, Clerc P, Avner P, Visvikis A, Branlant C. (2010)
2-D structure of the A region of Xist RNA and its implication for PRC2 association
PLoS Biol. 8(1):e1000276. doi:10.1371/journal.pbio.1000276
Europe PMC | doi


Navarro P, Chantalat S, Foglio M, Chureau C, Vigneau S, Clerc P, Avner P, Rougeulle C. (2009)
A role for non-coding Tsix transcription in partitioning chromatin domains within the mouse X-inactivation centre
Epigenetics Chromatin 2(1):8. doi:10.1186/1756-8935-2-8
Europe PMC | doi


Navarro P, Chambers I, Karwacki-Neisius V, Chureau C, Morey C, Rougeulle C, Avner P. (2008)
Molecular coupling of Xist regulation and pluripotency
Science 321(5896):1693-1695. doi:10.1126/science.1160952
Europe PMC | doi

Vallois D, Gagnerault MC, Avner P, Rogner UC, Boitard C, Benlagha K, Herbelin A, Lepault F. (2008)
Influence of a non-NK complex region of chromosome 6 on CD4+ invariant NK T cell homeostasis
J. Immunol. 181(3):1753-1759. doi:10.4049/jimmunol.181.3.1753
Europe PMC | doi


Attia M, Rachez C, De Pauw A, Avner P, Rogner UC. (2007)
Nap1l2 promotes histone acetylation activity during neuronal differentiation
Mol. Cell. Biol. 27(17):6093-6102. doi:10.1128/mcb.00789-07
Europe PMC | doi

Vallois D, Grimm CH, Avner P, Boitard C, Rogner UC. (2007)
The type 1 diabetes locus Idd6 controls TLR1 expression
J. Immunol. 179(6):3896-3903. doi:10.4049/jimmunol.179.6.3896
Europe PMC | doi


Ciaudo C, Bourdet A, Cohen-Tannoudji M, Dietz HC, Rougeulle C, Avner P. (2006)
Nuclear mRNA degradation pathway(s) are implicated in Xist regulation and X chromosome inactivation
PLoS Genet 2(6):874-882. doi:10.1371/journal.pgen.0020094
Europe PMC | doi

Clerc P, Avner P. (2006)
Random X-chromosome inactivation: skewing lessons for mice and men
Curr. Opin. Genet. Dev. 16(3):246-253. doi:10.1016/j.gde.2006.04.001
Europe PMC | doi

Duret L, Chureau C, Samain S, Weissenbach J, Avner P. (2006)
The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene
Science 312(5780):1653-1655. doi:10.1126/science.1126316
Europe PMC | doi

Vigneau S, Augui S, Navarro P, Avner P, Clerc P. (2006)
An essential role for the DXPas34 tandem repeat and Tsix transcription in the counting process of X chromosome inactivation
Proc. Natl. Acad. Sci. U.S.A. 103(19):7390-7395. doi:10.1073/pnas.0602381103
Europe PMC | doi


Okamoto I, Arnaud D, Le Baccon P, Otte AP, Disteche CM, Avner P, Heard E. (2005)
Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice
Nature 438(7066):369-373. doi:10.1038/nature04155
Europe PMC | doi

Navarro P, Pichard S, Ciaudo C, Avner P, Rougeulle C. (2005)
Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation
Genes Dev. 19(12):1474-1484. doi:10.1101/gad.341105
Europe PMC | doi

Kunath T, Arnaud D, Uy GD, Okamoto L, Chureau C, Yamanaka Y, Heard E, Gardner RL, Avner P, Rossant J. (2005)
Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts
Development 132(7):1649-1661. doi:10.1242/dev.01715
Europe PMC | doi


Auwerx J, Avner P, Baldock R, Ballabio A, Balling R, Barbacid M, Berns A, Bradley A, Brown S, Carmeliet P, Chambon P, Cox R, Davidson D, Davies K, Duboule D, Forejt J, Granucci F, Hastie N, de Angelis MH, Jackson I, Kioussis D, Kollias G, Lathrop M, Lendahl U, Malumbres M, von Melchner H, Müller W, Partanen J, Ricciardi-Castagnoli P, Rigby P, Rosen B, Rosenthal N, Skarnes B, Stewart AF, Thornton J, Tocchini-Valentini G, Wagner E, Wahli W, Wurst W. (2004)
The European dimension for the mouse genome mutagenesis program
Nat. Genet. 36(9):925-927. doi:10.1038/ng0904-925
Europe PMC | doi


Chureau C, Prissette M, Bourdet A, Barbe V, Cattolico L, Jones L, Eggen A, Avner P, Duret L. (2002)
Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine
Genome Res. 12(6):894-908. doi:10.1101/gr.152902
Europe PMC | doi


Heard E, Rougeulle C, Arnaud D, Avner P, Allis CD, Spector DL. (2001)
Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation
Cell 107(6):727-738. doi:10.1016/s0092-8674(01)00598-0
Europe PMC | doi

Avner P, Bruls T, Poras I, Eley L, Gas S, Ruiz P, Wiles MV, Sousa-Nunes R, Kettleborough R, Rana A, Morissette J, Bentley L, Goldsworthy M, Haynes A, Herbert E, Southam L, Lehrach H, Weissenbach J, Manenti G, Rodriguez-Tome P, Beddington R, Dunwoodie S, Cox RD. (2001)
A radiation hybrid transcript map of the mouse genome
Nat. Genet. 29(2):194-200. doi:10.1038/ng1001-194
Europe PMC | doi

Avner P, Heard E. (2001)
X-chromosome inactivation: Counting, choice and initiation
Nat. Rev. Genet. 2(1):59-67. doi:10.1038/35047580
Europe PMC | doi


Heard E, Avner P. (2000)
Trans-Siberian X press report - International Symposium on X Chromosome Inactivation in Mammals, Institute of Cytology and Genetics, Novosibirsk, Russia, 6-12 September, 1999
Paper presented at the International Symposium on X Chromosome Inactivation in Mammals, Institute of Cytology and Genetics, Novosibirsk, Russia, 6–12 September 1999.Trends Genet. 16(2):64-65. doi:10.1016/S0168-9525(99)01944-7
Europe PMC | doi


O'Neill LP, Keohane AM, Lavender JS, McCabe V, Heard E, Avner P, Brockdorff N, Turner BM. (1999)
A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation
EMBO J. 18(10):2897-2907. doi:10.1093/emboj/18.10.2897
Europe PMC | doi


Clerc P, Avner P. (1998)
Role of the region 3 ' to Xist exon 6 in the counting process of X-chromosome inactivation
Nat. Genet. 19(3):249-253. doi:10.1038/924
Europe PMC | doi


Heard E, Clerc P, Avner P. (1997)
X-chromosome inactivation in mammals
Annu. Rev. Genet. 31:571-610. doi:10.1146/annurev.genet.31.1.571
Europe PMC | doi


Courtier B, Heard E, Avner P. (1995)
Xce haplotypes show modified methylation in a region of the active X chromosome lying 3' to Xist
Proc. Natl. Acad. Sci. U.S.A. 92(8):3531-3535. doi:10.1073/pnas.92.8.3531
Europe PMC | doi


de Gouyon B, Melanitou E, Richard MF, Requarth M, Hahn IH, Guenet JL, Demenais F, Julier C, Lathrop GM, Boitard C, Avner P. (1993)
Genetic analysis of diabetes and insulitis in an interspecific cross of the nonobese diabetic mouse with Mus spretus
Proc. Natl. Acad. Sci. U.S.A. 90(5):1877-1881. doi:10.1073/pnas.90.5.1877
Europe PMC | doi


Avner P, Bućan M, Arnaud D, Lehrach H, Rapp U. (1987)
A-raf oncogene localizes on mouse X chromosome to region some 10-17 centimorgans proximal to hypoxanthine phosphoribosyltransferase gene
Somat. Cell Mol. Genet. 13(3):267-272. doi:10.1007/bf01535208
Europe PMC | doi


Dautigny A, Mattei MG, Morello D, Alliel PM, Pham-Dinh D, Amar L, Arnaud D, Simon D, Mattei JF, Guenet JL, Avner P. (1986)
The structural gene coding for myelin-associated proteolipid protein is mutated in jimpy mice
Nature 321(6073):867-869. doi:10.1038/321867a0
Europe PMC | doi


Amar LC, Arnaud D, Cambrou J, Guenet JL, Avner PR. (1985)
Mapping of the mouse X chromosome using random genomic probes and an interspecific mouse cross
EMBO J. 4(13B):3695-3700.
Europe PMC