Staff at EMBL

Dr. Cornelius Gross

Deputy Head of Outstation and Senior Scientist
Gross Group Joint appointment: Developmental Biology Unit

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

Biography

PhD 1995, Yale University.
Postdoctoral research at Columbia University.
Group leader at EMBL Monterotondo since 2003.
Deputy Head of Outstation and Senior Scientist since 2009.

Publications

The many paths to fear. Gross, C.T. & Canteras, N.S. Nat Rev Neurosci. 2012 Sep;13(9):651-8. doi: 10.1038/nrn3301. Epub 2012 Aug 1. PubMed

Validation of the dimensionality emergence assay for the measurement of innate anxiety in laboratory mice. Jain, A., Dvorkin, A., Fonio, E., Golani, I. & Gross, C.T. Eur Neuropsychopharmacol. 2012 Feb;22(2):153-63. Epub 2011 Jul 23. PubMed

Impaired Chemosensitivity of Mouse Dorsal Raphe Serotonergic Neurons Overexpressing Serotonin 1A (Htr1a) Receptors. Baccini, G., Mlinar, B., Audero, E., Gross, C.T. & Corradetti, R. PLoS One. 2012;7(9):e45072. doi: 10.1371/journal.pone.0045072. Epub 2012 Sep 13. PubMed

Synaptic pruning by microglia is necessary for normal brain development. Paolicelli, R.C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T.A., Guiducci, E., Dumas, L., Ragozzino, D. & Gross, C.T. Science. 2011 Sep 9;333(6048):1456-8. Epub 2011 Jul 21. PubMed

Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice. Ermakova, O., Piszczek, L., Luciani, L., Cavalli, F.M., Ferreira, T., Farley, D., Rizzo, S., Paolicelli, R.C., Al-Banchaabouchi, M., Nerlov, C., Moriggl, R., Luscombe, N.M. & Gross, C. EMBO Mol Med. 2011 Jan;3(1):50-66. doi: 10.1002/emmm.201000112. PubMed

Hidden Markov model analysis of maternal behavior patterns in inbred and reciprocal hybrid mice. Carola, V., Mirabeau, O. & Gross, C.T. PLoS One. 2011 Mar 8;6(3):e14753. PubMed

A neural switch for active and passive fear. Gozzi, A., Jain, A., Giovanelli, A., Bertollini, C., Crestan, V., Schwarz, A.J., Tsetsenis, T., Ragozzino, D., Gross, C.T. & Bifone, A. Neuron. 2010 Aug 26;67(4):656-66. PubMed

Increased vulnerability to psychosocial stress in heterozygous serotonin transporter knockout mice. Bartolomucci, A., Carola, V., Pascucci, T., Puglisi-Allegra, S., Cabib, S., Lesch, K.P., Parmigiani, S., Palanza, P. & Gross, C. Dis Model Mech. 2010 Jul-Aug;3(7-8):459-70. Epub 2010 Apr 6. PubMed

The consequence of natural selection on genetic variation in the mouse. Reuveni, E., Birney, E. & Gross, C.T. Genomics. 2010 Apr;95(4):196-202. Epub 2010 Feb 18. PubMed

Postnatal handling reverses social anxiety in serotonin receptor 1A knockout mice. Zanettini, C., Carola, V., Lo Iacono, L., Moles, A., Gross, C. & D'Amato, F.R. Genes Brain Behav. 2010 Feb;9(1):26-32. Epub 2009 Aug 8. PubMed

Could serotonin play a role in sudden infant death? Audero, E. & Gross, C. Pediatr Res. 2009 Feb;65(2):131. PubMed

Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. Audero, E., Coppi, E., Mlinar, B., Rossetti, T., Caprioli, A., Banchaabouchi, M.A., Corradetti, R. & Gross, C. Science. 2008 Jul 4;321(5885):130-3. PubMed

Alpha-Ca2+/calmodulin-dependent protein kinase II contributes to the developmental programming of anxiety in serotonin receptor 1A knock-out mice. Lo Iacono, L. & Gross, C. J Neurosci. 2008 Jun 11;28(24):6250-7. PubMed

Identifying molecular substrates in a mouse model of the serotonin transporter x environment risk factor for anxiety and depression. Carola, V., Frazzetto, G., Pascucci, T., Audero, E., Puglisi-Allegra, S., Cabib, S., Lesch, K.P. & Gross, C. Biol Psychiatry. 2008 May 1;63(9):840-6. Epub 2007 Oct 22. PubMed

GABA homeostasis contributes to the developmental programming of anxiety-related behavior. Depino, A.M., Tsetsenis, T. & Gross, C. Brain Res. 2008 Mar 18;. PubMed

Mating-related interactions share common features with anxiety in the mouse. Carola, V., Scalera, E., Brunamonti, E., Gross, C. & D'Amato, F. Behav Brain Res. 2008 Jan 25;186(2):185-90. Epub 2007 Aug 10. PubMed

Phenostat: visualization and statistical tool for analysis of phenotyping data. Reuveni, E., Carola, V., Al Banchaabouchi, M.A., Rosenthal, N., Hancock, J.M. & Gross, C. Mamm Genome. 2007 Aug 3;. PubMed

Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus. Tsetsenis, T., Ma, X.H., Lo Iacono, L., Beck, S.G. & Gross, C. Nat Neurosci. 2007 Jul;10(7):896-902. Epub 2007 Jun 3. PubMed

Beyond susceptibility. Behavioural genetics can advance our understanding of psychiatric disorders, but might not meet the expectations for new cures. Frazzetto, G. & Gross, C. EMBO Rep. 2007 Jul;8 Spec No:S3-6. PubMed

Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. Gutknecht, L., Jacob, C., Strobel, A., Kriegebaum, C., Muller, J., Zeng, Y., Markert, C., Escher, A., Wendland, J., Reif, A., Mossner, R., Gross, C., Brocke, B. & Lesch, K.P. Int J Neuropsychopharmacol. 2007 Jun;10(3):309-20. Epub 2006 Dec 19. PubMed

Identification of novel peptide hormones in the human proteome by hidden Markov model screening. Mirabeau, O., Perlas, E., Severini, C., Audero, E., Gascuel, O., Possenti, R., Birney, E., Rosenthal, N. & Gross, C. Genome Res. 2007 Mar;17(3):320-7. Epub 2007 Feb 6. PubMed

Simultaneous assessment of autonomic function and anxiety-related behavior in BALB/c and C57BL/6 mice. Depino, A.M. & Gross, C. Behav Brain Res. 2007 Feb 27;177(2):254-60. Epub 2007 Jan 3. PubMed

A novel conditional knockout strategy applied to serotonin receptors. Stark, K.L., Gross, C., Richardson-Jones, J., Zhuang, X. & Hen, R. Handb Exp Pharmacol. 2007;(178):347-63. PubMed

Mouse SNP Miner: an annotated database of mouse functional single nucleotide polymorphisms. Reuveni, E., Ramensky, V.E. & Gross, C. BMC Genomics. 2007 Jan 21;8:24. PubMed

Early trauma and increased risk for physical aggression during adulthood: the moderating role of MAOA genotype. Frazzetto, G., Di Lorenzo, G., Carola, V., Proietti, L., Sokolowska, E., Siracusano, A., Gross, C. & Troisi, A. PLoS ONE. 2007 May 30;2:e486. PubMed

Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons. Ragozzino, D., Di Angelantonio, S., Trettel, F., Bertollini, C., Maggi, L., Gross, C., Charo, I.F., Limatola, C. & Eusebi, F. J Neurosci. 2006 Oct 11;26(41):10488-98. PubMed

Fractalkine/CX3CL1 depresses central synaptic transmission in mouse hippocampal slices. Bertollini, C., Ragozzino, D., Gross, C., Limatola, C. & Eusebi, F. Neuropharmacology. 2006 Sep;51(4):816-21. Epub 2006 Jul 11. PubMed

Identifying interactions between genes and early environment in the mouse. Carola, V., Frazzetto, G. & Gross, C. Genes Brain Behav. 2006 Mar;5(2):189-99. PubMed

Increased fear response to contextual cues in mice lacking the 5-HT1A receptor. Klemenhagen, K.C., Gordon, J.A., David, D.J., Hen, R. & Gross, C.T. Neuropsychopharmacology. 2006 Jan;31(1):101-11. PubMed

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Walitza, S., Renner, T.J., Dempfle, A., Konrad, K., Wewetzer, C.h, Halbach, A., Herpertz-Dahlmann, B., Remschmidt, H., Smidt, J., Linder, M., Flierl, L., Knolker, U., Friedel, S., Schafer, H., Gross, C., Hebebrand, J., Warnke, A. & Lesch, K.P. Mol Psychiatry 2005 Dec;10(12):1126-32. PubMed

Age-dependent effects of serotonin-1A receptor gene deletion in spatial learning abilities in mice. Wolff, M., Costet, P., Gross, C., Hen, R., Segu, L. & Buhot, M.C. Brain Res Mol Brain Res 2004 Nov 4;130(1-2):39-48. PubMed

The developmental origins of anxiety. Gross, C. & Hen, R. Nat Rev Neurosci 2004 Jul;5(7):545-52. PubMed

Genetic and environmental factors interact to influence anxiety. Gross, C. & Hen, R. Neurotox Res 2004;6(6):493-501. PubMed

Book review: Nature via nurture (Ridley, M.) Gross, C. N. Engl. J. Med. 2004 350(4) 422

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Gross, C., Zhuang, X., Stark, K., Ramboz, S., Oosting, R., Kirby, L., Santarelli, L., Beck, S. & Hen, R. Nature 2002 Mar 28;416(6879):396-400. PubMed

Altered fear circuits in 5-HT(1A) receptor KO mice. Gross, C., Santarelli, L., Brunner, D., Zhuang, X. & Hen, R. Biol Psychiatry 2000 Dec 15;48(12):1157-63. PubMed

Regulation by homeoproteins: a comparison of deformed-responsive elements. Pederson, J.A., LaFollette, J.W., Gross, C., Veraksa, A., McGinnis, W. & Mahaffey, J.W. Genetics 2000 Oct;156(2):677-86. PubMed

Knockout mice reveal opposite roles for serotonin 1A and 1B receptors in prepulse inhibition. Dulawa, S.C., Gross, C., Stark, K.L., Hen, R. & Geyer, M.A. Neuropsychopharmacology 2000 Jun;22(6):650-9. PubMed

Altered Emotional States in Knockout Mice Lacking 5-HT1A or 5-HT1B Receptors. Zhuang, X., Gross, C., Santarelli, L., Compan, V., Trillat, A.C. & Hen, R. Neuropsychopharmacology 1999 Aug;21 Suppl 1:S52-60. PubMed

DEAF-1, a novel protein that binds an essential region in a Deformed response element. Gross, C.T. & McGinnis, W. EMBO J 1996 Apr 15;15(8):1961-70. PubMed

The function of homeodomain proteins in Drosophila development Gross, C.T. & McGinnis, W. In "Eukaryotic Gene Transcription: Frontiers in Molecular Biology." B.D. Hames and D.M. Glover (Eds). IRL Press, Oxford, UK

Antp-type homeodomains have distinct DNA binding specificities that correlate with their different regulatory functions in embryos. Dessain, S., Gross, C.T., Kuziora, M.A. & McGinnis, W. EMBO J 1992 Mar;11(3):991-1002. PubMed

Hemoglobin polymerization in sickle cells studied by circular polarized light scattering. Gross, C.T., Salamon, H., Hunt, A.J., Macey, R.I., Orme, F. & Quintanilha, A.T. Biochim Biophys Acta 1991 Aug 30;1079(2):152-60. PubMed