EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

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  • PhD 1995, Yale University.
    Postdoctoral research at Columbia University.
    Group leader at EMBL Monterotondo since 2003.
    Deputy Head of Outstation and Senior Scientist since 2009.
    ERC Advanced Investigator.


Total: 73 publication(s)


Rivero O, Selten MM, Sich S, Popp S, Bacmeister L, Amendola E, Negwer M, Schubert D, Proft F, Kiser D, Schmitt AG, Gross C, Kolk SM, Strekalova T, van den Hove D, Resink TJ, Nadif Kasri N, Lesch KP. (2015)

Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition.

Transl Psychiatry 5:e655. doi:10.1038/tp.2015.152
Europe PMC | doi

Samuels BA, Anacker C, Hu A, Levinstein MR, Pickenhagen A, Tsetsenis T, Madroñal N, Donaldson ZR, Drew LJ, Dranovsky A, Gross CT, Tanaka KF, Hen R. (2015)

5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response.

Nat Neurosci 18(11):1606-1616. doi:10.1038/nn.4116
Europe PMC | doi

Pagani F, Paolicelli RC, Murana E, Cortese B, Angelantonio SD, Zurolo E, Guiducci E, Ferreira TA, Garofalo S, Catalano M, D'Alessandra G, Porzia A, Peruzzi G, Mainiero F, Limatola C, Gross CT, Ragozzino D. (2015)

Defective microglial development in the hippocampus of Cx3cr1 deficient mice.

Front Cell Neurosci 9:111. doi:10.3389/fncel.2015.00111
Europe PMC | doi

Piszczek L, Piszczek A, Kuczmanska J, Audero E, Gross CT. (2015)

Modulation of anxiety by cortical serotonin 1A receptors.

Front Behav Neurosci 9 doi:10.3389/fnbeh.2015.00048
Europe PMC | doi


Fuchs C, Trazzi S, Torricella R, Viggiano R, De Franceschi M, Amendola E, Gross C, Calzà L, Bartesaghi R, Ciani E. (2014)

Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling

Neurobiol. Dis. 70:53-68. doi:10.1016/j.nbd.2014.06.006
Europe PMC | doi

Baroncelli L, Alessandrì MG, Tola J, Putignano E, Migliore M, Amendola E, Gross C, Leuzzi V, Cioni G, Pizzorusso T. (2014)

A novel mouse model of creatine transporter deficiency.

F1000Res 3 doi:10.12688/f1000research.5369.1
Europe PMC | doi

Carola V, Perlas E, Zonfrillo F, Soini HA, Novotny MV, Gross CT. (2014)

Modulation of social behavior by the agouti pigmentation gene

Front Behav Neurosci 8:259. doi:10.3389/fnbeh.2014.00259
Europe PMC | doi

Amendola E, Zhan Y, Mattucci C, Castroflorio E, Calcagno E, Fuchs C, Lonetti G, Silingardi D, Vyssotski AL, Farley D, Ciani E, Pizzorusso T, Giustetto M, Gross CT. (2014)

Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder

PLoS ONE 9(5):e91613. doi:10.1371/journal.pone.0091613
Europe PMC | doi

Zhan Y, Paolicelli RC, Sforazzini F, Weinhard L, Bolasco G, Pagani F, Vyssotski AL, Bifone A, Gozzi A, Ragozzino D, Gross CT. (2014)

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

Nat. Neurosci. 17(3):400-406. doi:10.1038/nn.3641
Europe PMC | doi


Silva BA, Mattucci C, Krzywkowski P, Murana E, Illarionova A, Grinevich V, Canteras NS, Ragozzino D, Gross CT. (2013)

Independent hypothalamic circuits for social and predator fear

Nat. Neurosci. 16(12):1731-1733. doi:10.1038/nn.3573
Europe PMC | doi

Piszczek L, Schlax K, Wyrzykowska A, Piszczek A, Audero E, Thilo Gross C. (2013)

Serotonin 1A auto-receptors are not sufficient to modulate anxiety in mice

Eur. J. Neurosci. 38(4):2621-2627. doi:10.1111/ejn.12260
Europe PMC | doi

Audero E, Mlinar B, Baccini G, Skachokova ZK, Corradetti R, Gross C. (2013)

Suppression of serotonin neuron firing increases aggression in mice

J. Neurosci. 33(20):8678-8688. doi:10.1523/jneurosci.2067-12.2013
Europe PMC | doi

Batti L, Mukhtarov M, Audero E, Ivanov A, Paolicelli O, Zurborg S, Gross C, Bregestovski P, Heppenstall PA. (2013)

Transgenic mouse lines for non-invasive ratiometric monitoring of intracellular chloride

Front Mol Neurosci 6:11. doi:10.3389/fnmol.2013.00011
Europe PMC | doi

Kuhn M, Al Banchaabouchi M, Campillos M, Jensen LJ, Gross C, Gavin AC, Bork P. (2013)

Systematic identification of proteins that elicit drug side effects

Mol. Syst. Biol. 9:663. doi:10.1038/msb.2013.10
Europe PMC | doi


Gross CT, Canteras NS. (2012)

The many paths to fear

Nat. Rev. Neurosci. 13(9):651-658. doi:10.1038/nrn3301
Europe PMC | doi

Ermakova O, Salimova E, Piszczek L, Gross C. (2012)

Construction and phenotypic analysis of mice carrying a duplication of the major histocompatibility class I (MHC-I) locus

Mamm. Genome 23(7-8):443-453. doi:10.1007/s00335-012-9401-7
Europe PMC | doi

Troisi A, Frazzetto G, Carola V, Di Lorenzo G, Coviello M, Siracusano A, Gross C. (2012)

Variation in the μ-opioid receptor gene (OPRM1) moderates the influence of early maternal care on fearful attachment

Soc Cogn Affect Neurosci 7(5):542-547. doi:10.1093/scan/nsr037
Europe PMC | doi

Gozzi A, Jain A, Giovannelli A, Bertollini C, Crestan V, Schwarz AJ, Tsetsenis T, Ragozzino D, Gross CT, Bifone A. (2012)

A Neural Switch for Active and Passive Fear (vol 67, pg 656, 2010)

NEURON 73(4):854. doi:10.1016/j.neuron.2012.02.007

Jain A, Dvorkin A, Fonio E, Golani I, Gross CT. (2012)

Validation of the dimensionality emergence assay for the measurement of innate anxiety in laboratory mice

Eur Neuropsychopharmacol 22(2):153-163. doi:10.1016/j.euroneuro.2011.07.001
Europe PMC | doi

Baccini G, Mlinar B, Audero E, Gross CT, Corradetti R. (2012)

Impaired chemosensitivity of mouse dorsal raphe serotonergic neurons overexpressing serotonin 1A (Htr1a) receptors

PLoS ONE 7(9):e45072. doi:10.1371/journal.pone.0045072
Europe PMC | doi

Carnevali L, Mastorci F, Audero E, Graiani G, Rossi S, Macchi E, Callegari S, Bartolomucci A, Nalivaiko E, Quaini F, Gross C, Sgoifo A. (2012)

Stress-induced susceptibility to sudden cardiac death in mice with altered serotonin homeostasis

PLoS ONE 7(7):e41184. doi:10.1371/journal.pone.0041184
Europe PMC | doi

Carola V, Gross C. (2012)

Mouse Models of the 5-HTTLPR × Stress Risk Factor for Depression

Curr Top Behav Neurosci 12:59-72. doi:10.1007/7854_2011_190
Europe PMC | doi


Paolicelli RC, Bolasco G, Pagani F, Maggi L, Scianni M, Panzanelli P, Giustetto M, Ferreira TA, Guiducci E, Dumas L, Ragozzino D, Gross CT. (2011)

Synaptic pruning by microglia is necessary for normal brain development

Science 333(6048):1456-1458. doi:10.1126/science.1202529
Europe PMC | doi

Kas MJ, Krishnan V, Gould TD, Collier DA, Olivier B, Lesch KP, Domenici E, Fuchs E, Gross C, Castrén E. (2011)

Advances in multidisciplinary and cross-species approaches to examine the neurobiology of psychiatric disorders

Eur Neuropsychopharmacol 21(7):532-544. doi:10.1016/j.euroneuro.2010.12.001
Europe PMC | doi

Cero C, Carola V, Palanza P, Gross C, Zukowska Z, Bartolomucci A. (2011)

Fat Depot-Specific Expression of the NPY System, Sympathetic-related and Adipogenic Markers in a Mouse Model of Chronic Psychosocial Stress


Carola V, Pascucci T, Puglisi-Allegra S, Cabib S, Gross C. (2011)

Effect of the interaction between the serotonin transporter gene and maternal environment on developing mouse brain

Behav. Brain Res. 217(1):188-194. doi:10.1016/j.bbr.2010.10.020
Europe PMC | doi

Paolicelli RC, Gross CT. (2011)

Microglia in development: linking brain wiring to brain environment

Neuron Glia Biol. 7(1):77-83. doi:10.1017/s1740925x12000105
Europe PMC | doi

Carola V, Mirabeau O, Gross CT. (2011)

Hidden Markov model analysis of maternal behavior patterns in inbred and reciprocal hybrid mice

PLoS ONE 6(3):e14753. doi:10.1371/journal.pone.0014753
Europe PMC | doi

Ermakova O, Piszczek L, Luciani L, Cavalli FM, Ferreira T, Farley D, Rizzo S, Paolicelli RC, Al-Banchaabouchi M, Nerlov C, Moriggl R, Luscombe NM, Gross C. (2011)

Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice

EMBO Mol Med 3(1):50-66. doi:10.1002/emmm.201000112
Europe PMC | doi

Troisi A, Frazzetto G, Carola V, Di Lorenzo G, Coviello M, D'Amato FR, Moles A, Siracusano A, Gross C. (2011)

Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients

Soc Neurosci 6(1):88-97. doi:10.1080/17470919.2010.482786
Europe PMC | doi


Gozzi A, Jain A, Giovannelli A, Bertollini C, Crestan V, Schwarz AJ, Tsetsenis T, Ragozzino D, Gross CT, Bifone A. (2010)

A neural switch for active and passive fear

Neuron 67(4):656-666. doi:10.1016/j.neuron.2010.07.008
Europe PMC | doi

Ferreira TA, Iacono LL, Gross CT. (2010)

Serotonin receptor 1A modulates actin dynamics and restricts dendritic growth in hippocampal neurons

Eur. J. Neurosci. 32(1):18-26. doi:10.1111/j.1460-9568.2010.07283.x
Europe PMC | doi

Carola V, Gross C. (2010)

BDNF moderates early environmental risk factors for anxiety in mouse

Genes Brain Behav. 9(4):379-389. doi:10.1111/j.1601-183x.2010.00572.x
Europe PMC | doi

Reuveni E, Birney E, Gross CT. (2010)

The consequence of natural selection on genetic variation in the mouse

Genomics 95(4):196-202. doi:10.1016/j.ygeno.2010.02.004
Europe PMC | doi

Zanettini C, Carola V, Lo Iacono L, Moles A, Gross C, D'Amato FR. (2010)

Postnatal handling reverses social anxiety in serotonin receptor 1A knockout mice

Genes Brain Behav. 9(1):26-32. doi:10.1111/j.1601-183x.2009.00531.x
Europe PMC | doi

Audero E, Mlinar B, Skachokova Z, Corradetti R, Gross C. (2010)

Altered aggressive behaviour following genetic and pharmacological manipulation of serotonin autoinhibition

Eur Neuropsychopharmacol 20:S167.
Europe PMC

Bartolomucci A, Carola V, Pascucci T, Puglisi-Allegra S, Cabib S, Lesch KP, Parmigiani S, Palanza P, Gross C. (2010)

Increased vulnerability to psychosocial stress in heterozygous serotonin transporter knockout mice

Dis Model Mech 3(7-8):459-470. doi:10.1242/dmm.004614
Europe PMC | doi


Audero E, Gross C. (2009)

Could serotonin play a role in sudden infant death?

Pediatr. Res. 65(2):131. doi:10.1203/pdr.0b013e318197b954
Europe PMC | doi


Gross C, Audero E. (2008)

Homing In on a SIDS Model Response

SCIENCE 322(5903):856-857.

Audero E, Coppi E, Mlinar B, Rossetti T, Caprioli A, Banchaabouchi MA, Corradetti R, Gross C. (2008)

Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition

Science 321(5885):130-133. doi:10.1126/science.1157871
Europe PMC | doi

Lo Iacono L, Gross C. (2008)

Alpha-Ca2+/calmodulin-dependent protein kinase II contributes to the developmental programming of anxiety in serotonin receptor 1A knock-out mice

Paper presented at the 10th Regional Meeting of the European-College-of-Neuropsychopharmacology, Tallinn, ESTONIA, APR 23-25, 2009. J. Neurosci. 28(24):6250-6257. doi:10.1523/jneurosci.5219-07.2008
Europe PMC | doi

Carola V, Frazzetto G, Pascucci T, Audero E, Puglisi-Allegra S, Cabib S, Lesch KP, Gross C. (2008)

Identifying molecular substrates in a mouse model of the serotonin transporter x environment risk factor for anxiety and depression

Biol. Psychiatry 63(9):840-846. doi:10.1016/j.biopsych.2007.08.013
Europe PMC | doi

Depino AM, Tsetsenis T, Gross C. (2008)

GABA homeostasis contributes to the developmental programming of anxiety-related behavior

Brain Res. 1210:189-199. doi:10.1016/j.brainres.2008.03.006
Europe PMC | doi

Carola V, Scalera E, Brunamonti E, Gross C, D'Amato F. (2008)

Mating-related interactions share common features with anxiety in the mouse

Behav. Brain Res. 186(2):185-190. doi:10.1016/j.bbr.2007.08.006
Europe PMC | doi


Reuveni E, Carola V, Banchaabouchi MA, Rosenthal N, Hancock JM, Gross C. (2007)

Phenostat: visualization and statistical tool for analysis of phenotyping data

Mamm. Genome 18(9):677-681. doi:10.1007/s00335-007-9042-4
Europe PMC | doi

Frazzetto G, Gross C. (2007)

Beyond susceptibility. Behavioural genetics can advance our understanding of psychiatric disorders, but might not meet the expectations for new cures

EMBO Rep. 8 Spec No:S3-6. doi:10.1038/sj.embor.7401013
Europe PMC | doi

Tsetsenis T, Ma XH, Lo Iacono L, Beck SG, Gross C. (2007)

Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus

Nat. Neurosci. 10(7):896-902. doi:10.1038/nn1919
Europe PMC | doi

Gutknecht L, Jacob C, Strobel A, Kriegebaum C, Müller J, Zeng Y, Markert C, Escher A, Wendland J, Reif A, Mössner R, Gross C, Brocke B, Lesch KP. (2007)

Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation

Int. J. Neuropsychopharmacol. 10(3):309-320. doi:10.1017/S1461145706007437
Europe PMC | doi

Mirabeau O, Perlas E, Severini C, Audero E, Gascuel O, Possenti R, Birney E, Rosenthal N, Gross C. (2007)

Identification of novel peptide hormones in the human proteome by hidden Markov model screening

Genome Res. 17(3):320-327. doi:10.1101/gr.5755407
Europe PMC | doi

Depino AM, Gross C. (2007)

Simultaneous assessment of autonomic function and anxiety-related behavior in BALB/c and C57BL/6 mice

Behav. Brain Res. 177(2):254-260. doi:10.1016/j.bbr.2006.11.025
Europe PMC | doi

Frazzetto G, Di Lorenzo G, Carola V, Proietti L, Sokolowska E, Siracusano A, Gross C, Troisi A. (2007)

Early trauma and increased risk for physical aggression during adulthood: the moderating role of MAOA genotype

PLoS ONE 2(5):e486. doi:10.1371/journal.pone.0000486
Europe PMC | doi

Reuveni E, Ramensky VE, Gross C. (2007)

Mouse SNP Miner: an annotated database of mouse functional single nucleotide polymorphisms

BMC Genomics 8:24. doi:10.1186/1471-2164-8-24
Europe PMC | doi

Stark KL, Gross C, Richardson-Jones J, Zhuang X, Hen R. (2007)

A novel conditional knockout strategy applied to serotonin receptors

Handb Exp Pharmacol (178):347-363. doi:10.1007/978-3-540-35109-2_14
Europe PMC | doi


Frazzetto G, Di Lorenzo G, Carola V, Proietti L, Siracusano A, Gross C, Troisi A. (2006)

Interactions between early traumatic life events, and MAO-Agenotype associated with increased physical aggression in adulthood

AM J MED GENET B 141B(7):743-744.

Ragozzino D, Di Angelantonio S, Trettel F, Bertollini C, Maggi L, Gross C, Charo IF, Limatola C, Eusebi F. (2006)

Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons

J. Neurosci. 26(41):10488-10498. doi:10.1523/jneurosci.3192-06.2006
Europe PMC | doi

Bertollini C, Ragozzino D, Gross C, Limatola C, Eusebi F. (2006)

Fractalkine/CX3CL1 depresses central synaptic transmission in mouse hippocampal slices

Neuropharmacology 51(4):816-821. doi:10.1016/j.neuropharm.2006.05.027
Europe PMC | doi

Carola V, Frazzetto G, Gross C. (2006)

Identifying interactions between genes and early environment in the mouse

Genes Brain Behav. 5(2):189-199. doi:10.1111/j.1601-183x.2005.00152.x
Europe PMC | doi

Klemenhagen KC, Gordon JA, David DJ, Hen R, Gross CT. (2006)

Increased fear response to contextual cues in mice lacking the 5-HT1A receptor

Neuropsychopharmacology 31(1):101-111. doi:10.1038/sj.npp.1300774
Europe PMC | doi


Walitza S, Renner TJ, Dempfle A, Konrad K, Wewetzer Ch, Halbach A, Herpertz-Dahlmann B, Remschmidt H, Smidt J, Linder M, Flierl L, Knölker U, Friedel S, Schäfer H, Gross C, Hebebrand J, Warnke A, Lesch KP. (2005)

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder

Mol. Psychiatry 10(12):1126-1132. doi:10.1038/sj.mp.4001734
Europe PMC | doi


Wolff M, Costet P, Gross C, Hen R, Segu L, Buhot MC. (2004)

Age-dependent effects of serotonin-1A receptor gene deletion in spatial learning abilities in mice

Brain Res. Mol. Brain Res. 130(1-2):39-48. doi:10.1016/j.molbrainres.2004.07.012
Europe PMC | doi

Gross C, Hen R. (2004)

The developmental origins of anxiety

Nat. Rev. Neurosci. 5(7):545-552. doi:10.1038/nrn1429
Europe PMC | doi

Gross C, Hen R. (2004)

Genetic and environmental factors interact to influence anxiety

Paper presented at the Meeting of the Fundacion-Cerebro-y-Mentre, SPAIN, 2003. Neurotox Res 6(6):493-501. doi:10.1007/bf03033286
Europe PMC | doi

Gross CT. (2004)

Book Review of Nature via Nurture: Genes, Experience, and What Makes Us Human

N. Engl. J. Med. 350(4):422.
Europe PMC


Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R. (2003)

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

Science 301(5634):805-809. doi:10.1126/science.1083328
Europe PMC | doi


Gross C, Zhuang X, Stark K, Ramboz S, Oosting R, Kirby L, Santarelli L, Beck S, Hen R. (2002)

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

Nature 416(6879):396-400. doi:10.1038/416396a
Europe PMC | doi


Gross C, Santarelli L, Brunner D, Zhuang X, Hen R. (2000)

Altered fear circuits in 5-HT(1A) receptor KO mice

Paper presented at the Conference on Genetics and Brain Function - Implications for the Treatment of Anxiety, WASHINGTON, D.C., MAR 22-23, 2000. Biol. Psychiatry 48(12):1157-1163. doi:10.1016/s0006-3223(00)01041-6
Europe PMC | doi

Pederson JA, LaFollette JW, Gross C, Veraksa A, McGinnis W, Mahaffey JW. (2000)

Regulation by homeoproteins: a comparison of deformed-responsive elements

Genetics 156(2):677-686.
Europe PMC

Dulawa SC, Gross C, Stark KL, Hen R, Geyer MA. (2000)

Knockout mice reveal opposite roles for serotonin 1A and 1B receptors in prepulse inhibition

Neuropsychopharmacology 22(6):650-659. doi:10.1016/s0893-133x(99)00164-5
Europe PMC | doi


Zhuang X, Gross C, Santarelli L, Compan V, Trillat AC, Hen R. (1999)

Altered emotional states in knockout mice lacking 5-HT1A or 5-HT1B receptors

Paper presented at the 50th Serotonin Anniversary Symposium, PRINCETON, NEW JERSEY, SEP 25-26, 1998. Neuropsychopharmacology 21(2 Suppl):52S-60S. doi:10.1016/S0893-133X(99)00047-0
Europe PMC | doi


Gross CT, McGinnis W. (1996)

DEAF-1, a novel protein that binds an essential region in a Deformed response element

EMBO J. 15(8):1961-1970.
Europe PMC

Gross CT, McGinnis W. (1996)

The function of homeodomain proteins in Drosophila development

In: Goodbourn S (ed.), Eukaryotic Gene Transcription. Frontiers in Molecular Biology, vol 12. Oxford University Press, New York, USA.


Dessain S, Gross CT, Kuziora MA, McGinnis W. (1992)

Antp-type homeodomains have distinct DNA binding specificities that correlate with their different regulatory functions in embryos

EMBO J. 11(3):991-1002.
Europe PMC


Gross CT, Salamon H, Hunt AJ, Macey RI, Orme F, Quintanilha AT. (1991)

Hemoglobin polymerization in sickle cells studied by circular polarized light scattering

Biochim. Biophys. Acta 1079(2):152-160. doi:10.1016/0167-4838(91)90120-o
Europe PMC | doi