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Staff at EMBL

Dr. Cornelius Gross

Deputy Head of Outstation and Senior Scientist
Gross Group Joint appointment: Developmental Biology Unit

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: send a mail


PhD 1995, Yale University.
Postdoctoral research at Columbia University.
Group leader at EMBL Monterotondo since 2003.
Deputy Head of Outstation and Senior Scientist since 2009.
ERC Advanced Investigator.


Modulation of social behavior by the agouti pigmentation gene. Carola, V., Perlas, E., Zonfrillo, F., Soini, H.A., Novotny, M.V. & Gross, C.T. Front Behav Neurosci. 2014 Aug 1;8:259. doi: 10.3389/fnbeh.2014.00259.eCollection 2014. Europe PMC

Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3beta signaling. Fuchs, C., Trazzi, S., Torricella, R., Viggiano, R., De Franceschi, M., Amendola, E., Gross, C., Calza, L., Bartesaghi, R. & Ciani, E. Neurobiol Dis. 2014 Jun 18. pii: S0969-9961(14)00170-3. doi:10.1016/j.nbd.2014.06.006. Europe PMC

Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder. Amendola, E., Zhan, Y., Mattucci, C., Castroflorio, E., Calcagno, E., Fuchs, C., Lonetti, G., Silingardi, D., Vyssotski, A.L., Farley, D., Ciani, E., Pizzorusso, T., Giustetto, M. & Gross, C.T. PLoS One. 2014 May 16;9(5):e91613. doi: 10.1371/journal.pone.0091613. eCollection2014. Europe PMC

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Zhan, Y., Paolicelli, R.C., Sforazzini, F., Weinhard, L., Bolasco, G., Pagani, F., Vyssotski, A.L., Bifone, A., Gozzi, A., Ragozzino, D. & Gross, C.T. Nat Neurosci. 2014 Mar;17(3):400-6. doi: 10.1038/nn.3641. Epub 2014 Feb 2. Europe PMC

Independent hypothalamic circuits for social and predator fear. Silva, B.A., Mattucci, C., Krzywkowski, P., Murana, E., Illarionova, A., Grinevich, V., Canteras, N.S., Ragozzino, D. & Gross, C.T. Nat Neurosci. 2013 Dec;16(12):1731-3. doi: 10.1038/nn.3573. Epub 2013 Nov 10. Europe PMC

Serotonin 1A auto-receptors are not sufficient to modulate anxiety in mice. Piszczek, L., Schlax, K., Wyrzykowska, A., Piszczek, A., Audero, E. & Thilo Gross, C. Eur J Neurosci. 2013 Aug;38(4):2621-7. doi: 10.1111/ejn.12260. Epub 2013 May 22. Europe PMC

Suppression of serotonin neuron firing increases aggression in mice. Audero, E., Mlinar, B., Baccini, G., Skachokova, Z.K., Corradetti, R. & Gross, C. J Neurosci. 2013 May 15;33(20):8678-88. doi: 10.1523/JNEUROSCI.2067-12.2013. Europe PMC

Systematic identification of proteins that elicit drug side effects. Kuhn, M., Al Banchaabouchi, M., Campillos, M., Jensen, L.J., Gross, C., Gavin, A.C. & Bork, P. Mol Syst Biol. 2013;9:663. doi: 10.1038/msb.2013.10. Europe PMC

Transgenic mouse lines for non-invasive ratiometric monitoring of intracellular chloride. Batti, L., Mukhtarov, M., Audero, E., Ivanov, A., Paolicelli, O., Zurborg, S., Gross, C., Bregestovski, P. & Heppenstall, P.A. Front Mol Neurosci. 2013;6:11. doi: 10.3389/fnmol.2013.00011. Europe PMC

The many paths to fear. Gross, C.T. & Canteras, N.S. Nat Rev Neurosci. 2012 Sep;13(9):651-8. doi: 10.1038/nrn3301. Epub 2012 Aug 1. Europe PMC

Construction and phenotypic analysis of mice carrying a duplication of the major histocompatibility class I (MHC-I) locus. Ermakova, O., Salimova, E., Piszczek, L. & Gross, C. Mamm Genome. 2012 Aug;23(7-8):443-53. doi: 10.1007/s00335-012-9401-7. Epub 2012Jul 7. Europe PMC

Stress-induced susceptibility to sudden cardiac death in mice with altered serotonin homeostasis. Carnevali, L., Mastorci, F., Audero, E., Graiani, G., Rossi, S., Macchi, E., Callegari, S., Bartolomucci, A., Nalivaiko, E., Quaini, F., Gross, C. & Sgoifo, A. PLoS One. 2012;7(7):e41184. doi: 10.1371/journal.pone.0041184. Epub 2012 Jul 18. Europe PMC

Variation in the mu-opioid receptor gene (OPRM1) moderates the influence of early maternal care on fearful attachment. Troisi, A., Frazzetto, G., Carola, V., Di Lorenzo, G., Coviello, M., Siracusano, A. & Gross, C. Soc Cogn Affect Neurosci. 2012 Jun;7(5):542-7. doi: 10.1093/scan/nsr037. Epub2011 Jul 8. Europe PMC

Validation of the dimensionality emergence assay for the measurement of innate anxiety in laboratory mice. Jain, A., Dvorkin, A., Fonio, E., Golani, I. & Gross, C.T. Eur Neuropsychopharmacol. 2012 Feb;22(2):153-63. Epub 2011 Jul 23. Europe PMC

Impaired Chemosensitivity of Mouse Dorsal Raphe Serotonergic Neurons Overexpressing Serotonin 1A (Htr1a) Receptors. Baccini, G., Mlinar, B., Audero, E., Gross, C.T. & Corradetti, R. PLoS One. 2012;7(9):e45072. doi: 10.1371/journal.pone.0045072. Epub 2012 Sep 13. Europe PMC

Synaptic pruning by microglia is necessary for normal brain development. Paolicelli, R.C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T.A., Guiducci, E., Dumas, L., Ragozzino, D. & Gross, C.T. Science. 2011 Sep 9;333(6048):1456-8. Epub 2011 Jul 21. Europe PMC

Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice. Ermakova, O., Piszczek, L., Luciani, L., Cavalli, F.M., Ferreira, T., Farley, D., Rizzo, S., Paolicelli, R.C., Al-Banchaabouchi, M., Nerlov, C., Moriggl, R., Luscombe, N.M. & Gross, C. EMBO Mol Med. 2011 Jan;3(1):50-66. doi: 10.1002/emmm.201000112. Europe PMC

Hidden Markov model analysis of maternal behavior patterns in inbred and reciprocal hybrid mice. Carola, V., Mirabeau, O. & Gross, C.T. PLoS One. 2011 Mar 8;6(3):e14753. Europe PMC

A neural switch for active and passive fear. Gozzi, A., Jain, A., Giovanelli, A., Bertollini, C., Crestan, V., Schwarz, A.J., Tsetsenis, T., Ragozzino, D., Gross, C.T. & Bifone, A. Neuron. 2010 Aug 26;67(4):656-66. Europe PMC

Increased vulnerability to psychosocial stress in heterozygous serotonin transporter knockout mice. Bartolomucci, A., Carola, V., Pascucci, T., Puglisi-Allegra, S., Cabib, S., Lesch, K.P., Parmigiani, S., Palanza, P. & Gross, C. Dis Model Mech. 2010 Jul-Aug;3(7-8):459-70. Epub 2010 Apr 6. Europe PMC

The consequence of natural selection on genetic variation in the mouse. Reuveni, E., Birney, E. & Gross, C.T. Genomics. 2010 Apr;95(4):196-202. Epub 2010 Feb 18. Europe PMC

Postnatal handling reverses social anxiety in serotonin receptor 1A knockout mice. Zanettini, C., Carola, V., Lo Iacono, L., Moles, A., Gross, C. & D'Amato, F.R. Genes Brain Behav. 2010 Feb;9(1):26-32. Epub 2009 Aug 8. Europe PMC

Could serotonin play a role in sudden infant death? Audero, E. & Gross, C. Pediatr Res. 2009 Feb;65(2):131. Europe PMC

Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. Audero, E., Coppi, E., Mlinar, B., Rossetti, T., Caprioli, A., Banchaabouchi, M.A., Corradetti, R. & Gross, C. Science. 2008 Jul 4;321(5885):130-3. Europe PMC

Alpha-Ca2+/calmodulin-dependent protein kinase II contributes to the developmental programming of anxiety in serotonin receptor 1A knock-out mice. Lo Iacono, L. & Gross, C. J Neurosci. 2008 Jun 11;28(24):6250-7. Europe PMC

GABA homeostasis contributes to the developmental programming of anxiety-related behavior. Depino, A.M., Tsetsenis, T. & Gross, C. Brain Res. 2008 May 19;1210:189-99. doi: 10.1016/j.brainres.2008.03.006. Epub2008 Mar 18. Europe PMC

Identifying molecular substrates in a mouse model of the serotonin transporter x environment risk factor for anxiety and depression. Carola, V., Frazzetto, G., Pascucci, T., Audero, E., Puglisi-Allegra, S., Cabib, S., Lesch, K.P. & Gross, C. Biol Psychiatry. 2008 May 1;63(9):840-6. Epub 2007 Oct 22. Europe PMC

Mating-related interactions share common features with anxiety in the mouse. Carola, V., Scalera, E., Brunamonti, E., Gross, C. & D'Amato, F. Behav Brain Res. 2008 Jan 25;186(2):185-90. Epub 2007 Aug 10. Europe PMC

Phenostat: visualization and statistical tool for analysis of phenotyping data. Reuveni, E., Carola, V., Al Banchaabouchi, M.A., Rosenthal, N., Hancock, J.M. & Gross, C. Mamm Genome. 2007 Aug 3;. Europe PMC

Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus. Tsetsenis, T., Ma, X.H., Lo Iacono, L., Beck, S.G. & Gross, C. Nat Neurosci. 2007 Jul;10(7):896-902. Epub 2007 Jun 3. Europe PMC

Beyond susceptibility. Behavioural genetics can advance our understanding of psychiatric disorders, but might not meet the expectations for new cures. Frazzetto, G. & Gross, C. EMBO Rep. 2007 Jul;8 Spec No:S3-6. Europe PMC

Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. Gutknecht, L., Jacob, C., Strobel, A., Kriegebaum, C., Muller, J., Zeng, Y., Markert, C., Escher, A., Wendland, J., Reif, A., Mossner, R., Gross, C., Brocke, B. & Lesch, K.P. Int J Neuropsychopharmacol. 2007 Jun;10(3):309-20. Epub 2006 Dec 19. Europe PMC

Identification of novel peptide hormones in the human proteome by hidden Markov model screening. Mirabeau, O., Perlas, E., Severini, C., Audero, E., Gascuel, O., Possenti, R., Birney, E., Rosenthal, N. & Gross, C. Genome Res. 2007 Mar;17(3):320-7. Epub 2007 Feb 6. Europe PMC

Simultaneous assessment of autonomic function and anxiety-related behavior in BALB/c and C57BL/6 mice. Depino, A.M. & Gross, C. Behav Brain Res. 2007 Feb 27;177(2):254-60. Epub 2007 Jan 3. Europe PMC

A novel conditional knockout strategy applied to serotonin receptors. Stark, K.L., Gross, C., Richardson-Jones, J., Zhuang, X. & Hen, R. Handb Exp Pharmacol. 2007;(178):347-63. Europe PMC

Mouse SNP Miner: an annotated database of mouse functional single nucleotide polymorphisms. Reuveni, E., Ramensky, V.E. & Gross, C. BMC Genomics. 2007 Jan 21;8:24. Europe PMC

Early trauma and increased risk for physical aggression during adulthood: the moderating role of MAOA genotype. Frazzetto, G., Di Lorenzo, G., Carola, V., Proietti, L., Sokolowska, E., Siracusano, A., Gross, C. & Troisi, A. PLoS ONE. 2007 May 30;2:e486. Europe PMC

Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons. Ragozzino, D., Di Angelantonio, S., Trettel, F., Bertollini, C., Maggi, L., Gross, C., Charo, I.F., Limatola, C. & Eusebi, F. J Neurosci. 2006 Oct 11;26(41):10488-98. Europe PMC

Fractalkine/CX3CL1 depresses central synaptic transmission in mouse hippocampal slices. Bertollini, C., Ragozzino, D., Gross, C., Limatola, C. & Eusebi, F. Neuropharmacology. 2006 Sep;51(4):816-21. Epub 2006 Jul 11. Europe PMC

Identifying interactions between genes and early environment in the mouse. Carola, V., Frazzetto, G. & Gross, C. Genes Brain Behav. 2006 Mar;5(2):189-99. Europe PMC

Increased fear response to contextual cues in mice lacking the 5-HT1A receptor. Klemenhagen, K.C., Gordon, J.A., David, D.J., Hen, R. & Gross, C.T. Neuropsychopharmacology. 2006 Jan;31(1):101-11. Europe PMC

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Walitza, S., Renner, T.J., Dempfle, A., Konrad, K., Wewetzer, C.h, Halbach, A., Herpertz-Dahlmann, B., Remschmidt, H., Smidt, J., Linder, M., Flierl, L., Knolker, U., Friedel, S., Schafer, H., Gross, C., Hebebrand, J., Warnke, A. & Lesch, K.P. Mol Psychiatry 2005 Dec;10(12):1126-32. Europe PMC

Age-dependent effects of serotonin-1A receptor gene deletion in spatial learning abilities in mice. Wolff, M., Costet, P., Gross, C., Hen, R., Segu, L. & Buhot, M.C. Brain Res Mol Brain Res 2004 Nov 4;130(1-2):39-48. Europe PMC

The developmental origins of anxiety. Gross, C. & Hen, R. Nat Rev Neurosci 2004 Jul;5(7):545-52. Europe PMC

Genetic and environmental factors interact to influence anxiety. Gross, C. & Hen, R. Neurotox Res 2004;6(6):493-501. Europe PMC

Book Review: Nature via Nurture: Genes, Experience, and What Makes Us Human (Ridley, M.). Gross, C. N. Engl. J. Med. 2004 350(4) 422

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Gross, C., Zhuang, X., Stark, K., Ramboz, S., Oosting, R., Kirby, L., Santarelli, L., Beck, S. & Hen, R. Nature 2002 Mar 28;416(6879):396-400. Europe PMC

Altered fear circuits in 5-HT(1A) receptor KO mice. Gross, C., Santarelli, L., Brunner, D., Zhuang, X. & Hen, R. Biol Psychiatry 2000 Dec 15;48(12):1157-63. Europe PMC

Regulation by homeoproteins: a comparison of deformed-responsive elements. Pederson, J.A., LaFollette, J.W., Gross, C., Veraksa, A., McGinnis, W. & Mahaffey, J.W. Genetics 2000 Oct;156(2):677-86. Europe PMC

Knockout mice reveal opposite roles for serotonin 1A and 1B receptors in prepulse inhibition. Dulawa, S.C., Gross, C., Stark, K.L., Hen, R. & Geyer, M.A. Neuropsychopharmacology 2000 Jun;22(6):650-9. Europe PMC

Altered emotional states in knockout mice lacking 5-HT1A or 5-HT1B receptors. Zhuang, X., Gross, C., Santarelli, L., Compan, V., Trillat, A.C. & Hen, R. Neuropsychopharmacology. 1999 Aug;21(2 Suppl):52S-60S. Europe PMC

DEAF-1, a novel protein that binds an essential region in a Deformed response element. Gross, C.T. & McGinnis, W. EMBO J 1996 Apr 15;15(8):1961-70. Europe PMC

The function of homeodomain proteins in Drosophila development Gross, C.T. & McGinnis, W. In "Eukaryotic Gene Transcription: Frontiers in Molecular Biology." B.D. Hames and D.M. Glover (Eds). IRL Press, Oxford, UK

Antp-type homeodomains have distinct DNA binding specificities that correlate with their different regulatory functions in embryos. Dessain, S., Gross, C.T., Kuziora, M.A. & McGinnis, W. EMBO J 1992 Mar;11(3):991-1002. Europe PMC

Hemoglobin polymerization in sickle cells studied by circular polarized light scattering. Gross, C.T., Salamon, H., Hunt, A.J., Macey, R.I., Orme, F. & Quintanilha, A.T. Biochim Biophys Acta 1991 Aug 30;1079(2):152-60. Europe PMC