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Research GroupsEMBL Monterotondo

Philip Avner

Philip Avner
Head of EMBL Monterotondo

Dynamic partnerships and exchanges with other international academic research and clinical centres, and participation in multiple EU-wide mouse research and informatics initiatives, are integral parts of our discovery process into genetics and genomics, cell biology and pathology.

The continued refinement and diversification of methodologies for introducing genetic and epigenetic perturbations of cellular and physiological function is allowing the outstation to generate ever more accurate mouse models of human disease and multigenic disorders. The use of engineered nucleases in particular is allowing the ‘democratisation’ of experimental perturbation to virtually any mouse strain, allowing much more sophisticated approaches to be applied to understanding the complex interactions occurring between genes and across the genome- interactions which will likely have both epigenetic and environmental components.

Research groups at EMBL Monterotondo are using these powerful tools to investigate wide-ranging aspects of mammalian biology, including gene expression during early embryogenesis, haemopoietic development and differentiation, cancer and regeneration, behaviour and sensory perception.

Overview on Research at EMBL Monterotondo

Avner Group Dynamics of epigenetic regulation
Gross Group Developmental programming of behaviour
Heppenstall Group Molecular physiology of somatosensation
Jechlinger Group Mechanisms of oncogene dependence and tumour relapse
Lancrin Group The haemogenic endothelium: a key stage in the generation of the first blood cells
O'Carroll Group RNA function in germ and stem cell biology
Rosenthal Group (Visiting) Regenerative mechanisms in heart and skeletal muscle
Sotillo - ERC Investigator Mitotic chromosomal instability and oncogene dependence

A state-of-art animal facility provides a full range of mouse transgenic and gene knock-out production, embryo rederivation and cryopreservation services, together with a specialised phenotyping suite. Other centralised facilities include histology, confocal microscopy and flow cytometry. The many interactions with groups on other EMBL campuses including through the Interdisciplinary Postdoctoral (EIPOD) Fellowship Programme provides exciting and continuing prospects for joint projects. Ongoing international collaborations include those with groups at the University of Florida, the MPI Freiburg, the EPFL in Lausanne, the Gordon Institute in Cambridge, the Institut Pasteur in Paris, and the CNIO in Madrid, Spain.

Philip Avner
Head of EMBL Monterotondo