Research GroupsEMBL Monterotondo
Philip Avner
Head of EMBL Monterotondo
Dynamic partnerships and exchanges with other international academic research and clinical centres, and participation in multiple EU-wide mouse research and informatics initiatives, are integral parts of our discovery process into genetics and genomics, cell biology and pathology.
The continued refinement of genetic and epigenetic perturbations of cellular and physiological function through the use of conditional and other increasingly finely engineered mouse mutations at the outstation is generating ever more accurate models of human disease and multigenic disorders.
Research groups at EMBL Monterotondo use these powerful tools to investigate wide-ranging aspects of mammalian biology, including gene expression, development and differentiation, cancer and regeneration, behaviour and sensory perception.
| Avner Group | Dynamics of epigenetic regulation |
| Gross Group | Developmental programming of behaviour |
| Heppenstall Group | Molecular physiology of somatosensation |
| Jechlinger Group | Mechanisms of oncogene dependence and tumour relapse |
| Minichiello Group (Visiting) | Signalling mechanisms and gene regulation in the nervous system |
| Lancrin Group | The haemogenic endothelium: a key stage in the generation of the first blood cells |
| O'Carroll Group | Non-coding RNA function and RNA modification in germ/stem cell biology |
| Rosenthal Group (Visiting) | Regenerative mechanisms in heart and skeletal muscle |
| Sotillo - ERC Investigator | Mitotic chromosomal instability and oncogene dependence |
A state-of-art animal facility provides a full range of mouse transgenic and gene knock-out production, embryo rederivation and cryopreservation services, and a fully phenotyping suite. Other centralised facilities include histology, confocal microscopy and flow cytometry. Interaction with groups at other EMBL campuses through the Interdisciplinary Postdoctoral (EIPOD) Fellowship Programme provides exciting new prospects for joint projects. Partnerships established with Imperial College London and with the Centre for Genomic Regulation (CRG) in Barcelona add additional opportunities for translational research.
Philip Avner
Head of EMBL Monterotondo