Staff at EMBL
Dr. Martin Jechlinger
Group Leader
Jechlinger Group
Joint appointment: Cell Biology and Biophysics Unit
EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy
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Biography
PhD 2002, Institute of Molecular Pathology (IMP) Vienna.
Postdoctoral research at Memorial Sloan-Kettering Cancer Center (MSKCC) New York.
Group leader at EMBL Monterotondo since 2010.
Publications
Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction. Jechlinger, M., Podsypanina, K. & Varmus, H. Genes Dev. 2009 Jul 15;23(14):1677-88. PubMed
Seeding and propagation of untransformed mouse mammary cells in the lung. Podsypanina, K., Du, Y.C., Jechlinger, M., Beverly, L.J., Hambardzumyan, D. & Varmus, H. Science. 2008 Sep 26;321(5897):1841-4. Epub 2008 Aug 28. PubMed
Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors. Siwko, S.K., Bu, W., Gutierrez, C., Lewis, B., Jechlinger, M., Schaffhausen, B. & Li, Y. Neoplasia. 2008 Jul;10(7):653-62, 1 p following 662. PubMed
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. Waerner, T., Alacakaptan, M., Tamir, I., Oberauer, R., Gal, A., Brabletz, T., Schreiber, M., Jechlinger, M. & Beug, H. Cancer Cell. 2006 Sep;10(3):227-39. PubMed
A crucial function of PDGF in TGF-beta-mediated cancer progression of hepatocytes. Gotzmann, J., Fischer, A.N., Zojer, M., Mikula, M., Proell, V., Huber, H., Jechlinger, M., Waerner, T., Weith, A., Beug, H. & Mikulits, W. Oncogene. 2006 May 25;25(22):3170-85. PubMed
Expression profiling of epithelial plasticity in tumor progression. Jechlinger, M., Grunert, S., Tamir, I.H., Janda, E., Lüdemann, S., Waerner, T., Seither, P., Weith, A., Beug, H. *, Kraut, N. *; *equal contribution Oncogene. 2003 Oct 16;22(46):7155-69.
Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Grunert, S., Jechlinger, M. & Beug, H. Nat Rev Mol Cell Biol. 2003 Aug;4(8):657-65. PubMed
Mechanisms in epithelial plasticity and metastasis: insights from 3D cultures and expression profiling. Jechlinger, M., Grunert, S. & Beug, H. J Mammary Gland Biol Neoplasia. 2002 Oct;7(4):415-32. PubMed
Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. Janda, E., Lehmann, K., Killisch, I., Jechlinger, M., Herzig, M., Downward, J., Beug, H., Grünert, S. J Cell Biol. 2002 Jan 21;156(2):299-313. Epub 2002 Jan 14.
Xenogenization by tetanus toxoid loading into lymphoblastoid cell lines and primary human tumor cells mediated by polycations and liposomes. Felzmann, T., Buchberger, M., Jechlinger, M., Kircheis, R., Wagner, E. & Gadner, H. Cancer Lett. 2000 Dec 20;161(2):241-50. PubMed
Structure and subunit composition of GABA(A) receptors. Sieghart, W., Fuchs, K., Tretter, V., Ebert, V., Jechlinger, M., Höger, H., Adamiker, D. Neurochem Int. 1999 May;34(5):379-85. Review.
Subunit composition and quantitative importance of hetero-oligomeric receptors: GABAA receptors containing alpha6 subunits. Jechlinger, M., Pelz, R., Tretter, V., Klausberger, T. & Sieghart, W. J Neurosci. 1998 Apr 1;18(7):2449-57. PubMed