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Staff at EMBL

Dr. Martin Jechlinger

Group Leader
Jechlinger Group Joint appointment: Cell Biology and Biophysics Unit

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: send a mail

Biography

PhD 2002, Institute of Molecular Pathology (IMP) Vienna.
Postdoctoral research at Memorial Sloan-Kettering Cancer Center (MSKCC) New York.
Group leader at EMBL Monterotondo since 2010.

Publications

Culturing Mouse Tumor Cells. Rhim, A.D., Jechlinger, M. & Rustgi, A.K. In: Shen, C., Politi, K., Chodosh, L. & Olive, K. (eds., 2014). Mouse models of cancer: a laboratory manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press, pp. 401-426.

Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction. Jechlinger, M., Podsypanina, K. & Varmus, H. Genes Dev. 2009 Jul 15;23(14):1677-88. Europe PMC

Seeding and propagation of untransformed mouse mammary cells in the lung. Podsypanina, K., Du, Y.C., Jechlinger, M., Beverly, L.J., Hambardzumyan, D. & Varmus, H. Science. 2008 Sep 26;321(5897):1841-4. Epub 2008 Aug 28. Europe PMC

Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors. Siwko, S.K., Bu, W., Gutierrez, C., Lewis, B., Jechlinger, M., Schaffhausen, B. & Li, Y. Neoplasia. 2008 Jul;10(7):653-62, 1 p following 662. Europe PMC

ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. Waerner, T., Alacakaptan, M., Tamir, I., Oberauer, R., Gal, A., Brabletz, T., Schreiber, M., Jechlinger, M. & Beug, H. Cancer Cell. 2006 Sep;10(3):227-39. Europe PMC

A crucial function of PDGF in TGF-beta-mediated cancer progression of hepatocytes. Gotzmann, J., Fischer, A.N., Zojer, M., Mikula, M., Proell, V., Huber, H., Jechlinger, M., Waerner, T., Weith, A., Beug, H. & Mikulits, W. Oncogene. 2006 May 25;25(22):3170-85. Europe PMC

Expression profiling of epithelial plasticity in tumor progression. Jechlinger, M., Grunert, S., Tamir, I.H., Janda, E., Ludemann, S., Waerner, T., Seither, P., Weith, A., Beug, H.* & Kraut, N.* Oncogene. 2003 Oct 16;22(46):7155-69.
* equal contribution Europe PMC

Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Grunert, S., Jechlinger, M. & Beug, H. Nat Rev Mol Cell Biol. 2003 Aug;4(8):657-65. Europe PMC

Mechanisms in epithelial plasticity and metastasis: insights from 3D cultures and expression profiling. Jechlinger, M., Grunert, S. & Beug, H. J Mammary Gland Biol Neoplasia. 2002 Oct;7(4):415-32. Europe PMC

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. Janda, E., Lehmann, K., Killisch, I., Jechlinger, M., Herzig, M., Downward, J., Beug, H. & Grunert, S. J Cell Biol. 2002 Jan 21;156(2):299-313. Epub 2002 Jan 14. Europe PMC

Xenogenization by tetanus toxoid loading into lymphoblastoid cell lines and primary human tumor cells mediated by polycations and liposomes. Felzmann, T., Buchberger, M., Jechlinger, M., Kircheis, R., Wagner, E. & Gadner, H. Cancer Lett. 2000 Dec 20;161(2):241-50. Europe PMC

Structure and subunit composition of GABA(A) receptors. Sieghart, W., Fuchs, K., Tretter, V., Ebert, V., Jechlinger, M., Höger, H., Adamiker, D. Neurochem Int. 1999 May;34(5):379-85. Review.

Subunit composition and quantitative importance of hetero-oligomeric receptors: GABAA receptors containing alpha6 subunits. Jechlinger, M., Pelz, R., Tretter, V., Klausberger, T. & Sieghart, W. J Neurosci. 1998 Apr 1;18(7):2449-57. Europe PMC