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Staff at EMBL


Dr. Martin Jechlinger

Group Leader
Jechlinger Group Joint appointment: Cell Biology and Biophysics Unit

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: send a mail


PhD 2002, Institute of Molecular Pathology (IMP) Vienna.
Postdoctoral research at Memorial Sloan-Kettering Cancer Center (MSKCC) New York.
Group leader at EMBL Monterotondo since 2010.


Total: 14 publication(s)


Rhim AD, Jechlinger M, Rustgi AK. (2014)
Culturing Mouse Tumor Cells
In: Abate-Shen C, Politi K, Chodosh LA, Olive KP (eds.), Mouse models of cancer: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. pp 401-426.


Jechlinger M, Podsypanina K, Varmus H. (2009)
Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction
Genes Dev. 23(14):1677-1688. doi:10.1101/gad.1801809
Europe PMC | doi


Podsypanina K, Du YC, Jechlinger M, Beverly LJ, Hambardzumyan D, Varmus H. (2008)
Seeding and propagation of untransformed mouse mammary cells in the lung
Science 321(5897):1841-1844. doi:10.1126/science.1161621
Europe PMC | doi

Siwko SK, Bu W, Gutierrez C, Lewis B, Jechlinger M, Schaffhausen B, Li Y. (2008)
Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors
Neoplasia 10(7):653-62, 1 p following 662.
Europe PMC


Waerner T, Alacakaptan M, Tamir I, Oberauer R, Gal A, Brabletz T, Schreiber M, Jechlinger M, Beug H. (2006)
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells
Cancer Cell 10(3):227-239. doi:10.1016/j.ccr.2006.07.020
Europe PMC | doi

Jechlinger M, Sommer A, Moriggl R, Seither P, Kraut N, Capodiecci P, Donovan M, Cordon-Cardo C, Beug H, Grünert S. (2006)
Autocrine PDGFR signaling promotes mammary cancer metastasis
J. Clin. Invest. 116(6):1561-1570. doi:10.1172/jci24652
Europe PMC | doi

Gotzmann J, Fischer AN, Zojer M, Mikula M, Proell V, Huber H, Jechlinger M, Waerner T, Weith A, Beug H, Mikulits W. (2006)
A crucial function of PDGF in TGF-beta-mediated cancer progression of hepatocytes
Oncogene 25(22):3170-3185. doi:10.1038/sj.onc.1209083
Europe PMC | doi


Jechlinger M, Grunert S, Tamir IH, Janda E, Lüdemann S, Waerner T, Seither P, Weith A, Beug H, Kraut N. (2003)
Expression profiling of epithelial plasticity in tumor progression
Oncogene 22(46):7155-7169. doi:10.1038/sj.onc.1206887
Europe PMC | doi

Grünert S, Jechlinger M, Beug H. (2003)
Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis
Nat. Rev. Mol. Cell Biol. 4(8):657-665. doi:10.1038/nrm1175
Europe PMC | doi


Jechlinger M, Grünert S, Beug H. (2002)
Mechanisms in epithelial plasticity and metastasis: insights from 3D cultures and expression profiling
J Mammary Gland Biol Neoplasia 7(4):415-432. doi:10.1023/a:1024090116451
Europe PMC | doi

Janda E, Lehmann K, Killisch I, Jechlinger M, Herzig M, Downward J, Beug H, Grünert S. (2002)
Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways
J. Cell Biol. 156(2):299-313. doi:10.1083/jcb.200109037
Europe PMC | doi


Felzmann T, Buchberger M, Jechlinger M, Kircheis R, Wagner E, Gadner H. (2000)
Xenogenization by tetanus toxoid loading into lymphoblastoid cell lines and primary human tumor cells mediated by polycations and liposomes
Cancer Lett. 161(2):241-250. doi:10.1016/s0304-3835(00)00618-2
Europe PMC | doi


Sieghart W, Fuchs K, Tretter V, Ebert V, Jechlinger M, Höger H, Adamiker D. (1999)
Structure and subunit composition of GABA(A) receptors
Neurochem. Int. 34(5):379-385. doi:10.1016/s0197-0186(99)00045-5
Europe PMC | doi


Jechlinger M, Pelz R, Tretter V, Klausberger T, Sieghart W. (1998)
Subunit composition and quantitative importance of hetero-oligomeric receptors: GABAA receptors containing alpha6 subunits
J. Neurosci. 18(7):2449-2457.
Europe PMC