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Staff at EMBL

Dr. Rocio Sotillo

Staff Scientist
Sotillo ERC Investigator Jechlinger Group

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: send a mail

Biography

PhD 2002, Autónoma University (Madrid) and Spanish National Cancer Center (CNIO), Spain.
Posdoctoral work at Memorial Sloan Kettering Cancer Center, New York, USA.
At EMBL since September 2010.
ERC investigator since 2011.
HHMI International Early Career Scientist.

Publications

Is aneuploidy deciding your fate? Rowald, K. & Sotillo, R. Cell Cycle. 2014 Apr 3;13(9). Europe PMC

Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition. Schvartzman, J.M., Duijf, P.H., Sotillo, R., Coker, C. & Benezra, R. Cancer Cell. 2011 Jun 14;19(6):701-14. doi: 10.1016/j.ccr.2011.04.017. Europe PMC

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Sotillo, R., Schvartzman, J.M., Socci, N.D. & Benezra, R. Nature. 2010 Mar 18;464(7287):436-40. Epub 2010 Feb 21. Europe PMC

Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Schvartzman*, J.M., Sotillo*, R. & Benezra, R. Nat Rev Cancer. 2010 Feb;10(2):102-15.
* equal contribution Europe PMC

Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity. Sotillo, R., Schvartzman, J.M. & Benezra, R. Cancer Cell. 2009 Dec 8;16(6):451-2. Europe PMC

Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo. Diaz-Rodriguez, E.*, Sotillo, R.*, Schvartzman, J.M. & Benezra, R. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16719-24. doi:10.1073/pnas.0803504105. Epub 2008 Oct 21.
* equal contribution Europe PMC

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Sotillo, R., Hernando, E., Diaz-Rodriguez, E., Teruya-Feldstein, J., Cordon-Cardo, C., Lowe, S.W. & Benezra, R. Cancer Cell. 2007 Jan;11(1):9-23. Epub 2006 Dec 28. Europe PMC

Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I. Niault, T., Hached, K., Sotillo, R., Sorger, P.K., Maro, B., Benezra, R. & Wassmann, K. PLoS One. 2007 Nov 28;2(11):e1165. Europe PMC

Autocrine PDGFR signaling promotes mammary cancer metastasis. Jechlinger, M., Sommer, A., Moriggl, R., Seither, P., Kraut, N., Capodiecci, P., Donovan, M., Cordon-Cardo, C., Beug, H. & Grunert, S. J Clin Invest. 2006 Jun;116(6):1561-70. Europe PMC

Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity. Sotillo, R., Renner, O., Dubus, P., Ruiz-Cabello, J., Martin-Caballero, J., Barbacid, M., Carnero, A. & Malumbres, M. Cancer Res. 2005 May 1;65(9):3846-52. Europe PMC

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Malumbres, M., Sotillo, R., Santamaria, D., Galan, J., Cerezo, A., Ortega, S., Dubus, P. & Barbacid, M. Cell. 2004 Aug 20;118(4):493-504. Europe PMC

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Ortega, S., Prieto, I., Odajima, J., Martin, A., Dubus, P., Sotillo, R., Barbero, J.L., Malumbres, M. & Barbacid, M. Nat Genet. 2003 Sep;35(1):25-31. Epub 2003 Aug 17. Europe PMC

Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Martin, J., Hunt, S.L., Dubus, P., Sotillo, R., Nehme-Pelluard, F., Magnuson, M.A., Parlow, A.F., Malumbres, M., Ortega, S. & Barbacid, M. Oncogene. 2003 Aug 14;22(34):5261-9. Europe PMC

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. Sotillo, R., Dubus, P., Martin, J., de la Cueva, E., Ortega, S., Malumbres, M. & Barbacid, M. EMBO J. 2001 Dec 3;20(23):6637-47. Europe PMC

Invasive melanoma in Cdk4-targeted mice. Sotillo, R., Garcia, J.F., Ortega, S., Martin, J., Dubus, P., Barbacid, M. & Malumbres, M. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13312-7. Epub 2001 Oct 23. Europe PMC

Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. Latres, E., Malumbres, M., Sotillo, R., Martin, J., Ortega, S., Martin-Caballero, J., Flores, J.M., Cordon-Cardo, C. & Barbacid, M. EMBO J. 2000 Jul 3;19(13):3496-506. Europe PMC