EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: Send a mail


  • PhD 2002, Autónoma University (Madrid) and Spanish National Cancer Center (CNIO), Spain.
    Posdoctoral work at Memorial Sloan Kettering Cancer Center, New York, USA.
    At EMBL since September 2010.
    ERC investigator since 2011.
    HHMI International Early Career Scientist.


Total: 18 publication(s)


Rowald K, Mantovan M, Passos J, Buccitelli C, Mardin BR, Korbel JO, Jechlinger M, Sotillo R. (2016)

Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth.

Cell Rep 15(12):2679-2691. doi: 10.1016/j.celrep.2016.05.048
Europe PMC | doi


Rowald K, Sotillo R. (2014)

Is aneuploidy deciding your fate?

Cell Cycle 13(9):1370. doi: 10.4161/cc.28753
Europe PMC | doi


Schvartzman JM, Duijf PH, Sotillo R, Coker C, Benezra R. (2011)

Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition

Cancer Cell 19(6):701-714. doi: 10.1016/j.ccr.2011.04.017
Europe PMC | doi


Sotillo R, Schvartzman JM, Socci ND, Benezra R. (2010)

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

Nature 464(7287):436-440. doi: 10.1038/nature08803
Europe PMC | doi

Schvartzman JM, Sotillo R, Benezra R. (2010)

Mitotic chromosomal instability and cancer: mouse modelling of the human disease

Nat. Rev. Cancer 10(2):102-115. doi: 10.1038/nrc2781
Europe PMC | doi


Sotillo R, Schvartzman JM, Benezra R. (2009)

Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity

Cancer Cell 16(6):451-452. doi: 10.1016/j.ccr.2009.11.014
Europe PMC | doi


Diaz-Rodríguez E, Sotillo R, Schvartzman JM, Benezra R. (2008)

Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo

Proc. Natl. Acad. Sci. U.S.A. 105(43):16719-16724. doi: 10.1073/pnas.0803504105
Europe PMC | doi


Niault T, Hached K, Sotillo R, Sorger PK, Maro B, Benezra R, Wassmann K. (2007)

Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I

PLoS ONE 2(11):e1165. doi: 10.1371/journal.pone.0001165
Europe PMC | doi

Sotillo R, Hernando E, Díaz-Rodríguez E, Teruya-Feldstein J, Cordón-Cardo C, Lowe SW, Benezra R. (2007)

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

Cancer Cell 11(1):9-23. doi: 10.1016/j.ccr.2006.10.019
Europe PMC | doi


Sotillo R, Renner O, Dubus P, Ruiz-Cabello J, Martín-Caballero J, Barbacid M, Carnero A, Malumbres M. (2005)

Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity

Cancer Res. 65(9):3846-3852. doi: 10.1158/0008-5472.can-04-4195
Europe PMC | doi

Barbacid M, Ortega S, Sotillo R, Odajima J, Martín A, Santamaría D, Dubus P, Malumbres M. (2005)

Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases

Cold Spring Harb. Symp. Quant. Biol. 70:233-240. doi: 10.1101/sqb.2005.70.005
Europe PMC | doi


Malumbres M, Sotillo R, Santamaría D, Galán J, Cerezo A, Ortega S, Dubus P, Barbacid M. (2004)

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

Cell 118(4):493-504. doi: 10.1016/j.cell.2004.08.002
Europe PMC | doi


Ortega S, Prieto I, Odajima J, Martín A, Dubus P, Sotillo R, Barbero JL, Malumbres M, Barbacid M. (2003)

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

Nat. Genet. 35(1):25-31. doi: 10.1038/ng1232
Europe PMC | doi

Martín J, Hunt SL, Dubus P, Sotillo R, Néhmé-Pélluard F, Magnuson MA, Parlow AF, Malumbres M, Ortega S, Barbacid M. (2003)

Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number

Oncogene 22(34):5261-5269. doi: 10.1038/sj.onc.1206506
Europe PMC | doi

Malumbres M, Hunt SL, Sotillo R, Martín J, Odajima J, Martín A, Dubus P, Ortega S, Barbacid M. (2003)

Driving the cell cycle to cancer

Adv. Exp. Med. Biol. 532:1-11. doi: 10.1007/978-1-4615-0081-0_1
Europe PMC | doi


Sotillo R, Dubus P, Martín J, de la Cueva E, Ortega S, Malumbres M, Barbacid M. (2001)

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors

EMBO J. 20(23):6637-6647. doi: 10.1093/emboj/20.23.6637
Europe PMC | doi

Sotillo R, García JF, Ortega S, Martin J, Dubus P, Barbacid M, Malumbres M. (2001)

Invasive melanoma in Cdk4-targeted mice

Proc. Natl. Acad. Sci. U.S.A. 98(23):13312-13317. doi: 10.1073/pnas.241338598
Europe PMC | doi


Latres E, Malumbres M, Sotillo R, Martín J, Ortega S, Martín-Caballero J, Flores JM, Cordón-Cardo C, Barbacid M. (2000)

Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

EMBO J. 19(13):3496-3506. doi: 10.1093/emboj/19.13.3496
Europe PMC | doi