Minichiello Group (Visiting)Publications
TrkB modulates fear learning and amygdalar synaptic plasticity by specific docking sites.
Musumeci, G., Sciarretta, C., Rodriguez-Moreno, A., Al Banchaabouchi, M., Negrete-Diaz, V., Costanzi, M., Berno, V., Egorov, A.V., von Bohlen Und Halbach, O., Cestari, V., Delgado-Garcia, J.M. & Minichiello, L.
J Neurosci. 2009 Aug 12;29(32):10131-43. PubMed
TrkB but not trkC receptors are necessary for postnatal maintenance of hippocampal spines.
von Bohlen und Halbach, O., Minichiello, L. & Unsicker, K.
Neurobiol Aging. 2008 Aug;29(8):1247-55. Epub 2007 Apr 17. PubMed
Increased dopamine after mating impairs olfaction and prevents odor interference with pregnancy.
Serguera, C., Triaca, V., Kelly-Barrett, J., Banchaabouchi, M.A. & Minichiello, L.
Nat Neurosci. 2008 Aug;11(8):949-56. Epub 2008 Jul 20. PubMed
BDNF production by olfactory ensheathing cells contributes to axonal regeneration of cultured adult CNS neurons.
Pastrana, E., Moreno-Flores, M.T., Avila, J., Wandosell, F., Minichiello, L. & Diaz-Nido, J.
Neurochem Int. 2007 Feb;50(3):491-8. Epub 2006 Dec 8. PubMed
Mutation at the TrkB PLC{gamma}-docking site affects hippocampal LTP and associative learning in conscious mice.
Gruart, A., Sciarretta, C., Valenzuela-Harrington, M., Delgado-Garcia, J.M. & Minichiello, L.
Learn Mem. 2007 Jan-Feb;14(1):54-62. PubMed
Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription.
Calella, A.M., Nerlov, C., Lopez, R.G., Sciarretta, C., von Bohlen Und Halbach, O., Bereshchenko, O. & Minichiello, L.
Neural Develop. 2007 Jan 25;2:4. PubMed
Neurotrophin receptor heterozygosity causes deficits in catecholaminergic innervation of amygdala and hippocampus in aged mice.
von Bohlen Und Halbach, O. & Minichiello, L.
J Neural Transm. 2006 Dec;113(12):1829-36. Epub 2006 Jun 1. PubMed
Brain-derived neurotrophic factor selectively regulates dendritogenesis of parvalbumin-containing interneurons in the main olfactory bulb through the PLCgamma pathway.
Berghuis, P., Agerman, K., Dobszay, M.B., Minichiello, L., Harkany, T. & Ernfors, P.
J Neurobiol. 2006 Nov;66(13):1437-51. PubMed
Regional- and age-dependent reduction in trkB receptor expression in the hippocampus is associated with altered spine morphologies.
von Bohlen und Halbach, O., Krause, S., Medina, D., Sciarretta, C., Minichiello, L. & Unsicker, K.
Biol Psychiatry. 2006 May 1;59(9):793-800. Epub 2005 Dec 1. PubMed
Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase Cgamma signaling.
Gartner, A., Polnau, D.G., Staiger, V., Sciarretta, C., Minichiello, L., Thoenen, H., Bonhoeffer, T. & Korte, M.
J Neurosci. 2006 Mar 29;26(13):3496-504. PubMed
Apoptosis of oligodendrocytes via fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis.
Hovelmeyer, N., Hao, Z., Kranidioti, K., Kassiotis, G., Buch, T., Frommer, F., von Hoch, L., Kramer, D., Minichiello, L., Kollias, G., Lassmann, H. & Waisman, A.
J Immunol 2005 Nov 1;175(9):5875-84. PubMed
Haploin-sufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra.
von Bohlen und Halbach, O., Minichiello, L. & Unsicker, K.
FASEB J 2005 Oct;19(12):1740-2. Epub 2005 Jul 21. PubMed
Genetic evidence for selective neurotrophin 3 signalling through TrkC but not TrkB in vivo.
Stenqvist, A., Agerman, K., Marmigere, F., Minichiello, L. & Ernfors, P.
EMBO Rep 2005 Oct;6(10):973-8. PubMed
TrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migration.
Medina, D.L., Sciarretta, C., Calella, A.M., Von Bohlen Und Halbach, O., Unsicker, K. & Minichiello, L.
EMBO J 2004 Sep 29;23(19):3803-14. Epub 2004 Sep 16. PubMed
Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2.
Rivera, C., Voipio, J., Thomas-Crusells, J., Li, H., Emri, Z., Sipila, S., Payne, J.A., Minichiello, L., Saarma, M. & Kaila, K.
J Neurosci 2004 May 12;24(19):4683-91. PubMed
Haploin sufficiency in trkB and/or trkC neurotrophin receptors causes structural alterations in the aged hippocampus and amygdala.
von Bohlen und Halbach, O., Minichiello, L. & Unsicker, K.
Eur J Neurosci 2003 Oct;18(8):2319-25. PubMed
Lack of Bdnf and TrkB signalling in the postnatal cochlea leads to a spatial reshaping of innervation along the tonotopic axis and hearing loss.
Schimmang, T., Tan, J., Muller, M., Zimmermann, U., Rohbock, K., Kopschall, I., Limberger, A., Minichiello, L. & Knipper, M.
Development 2003 Oct;130(19):4741-50. PubMed
Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia.
Lucas, G., Hendolin, P., Harkany, T., Agerman, K., Paratcha, G., Holmgren, C., Zilberter, Y., Sairanen, M., Minichiello, L., Castren, E. & Ernfors, P.
Nat Neurosci 2003 Mar;6(3):221-2. PubMed
Mechanism of TrkB-mediated hippocampal long-term potentiation.
Minichiello, L., Calella, A.M., Medina, D.L., Bonhoeffer, T., Klein, R. & Korte, M.
Neuron 2002 Sep 26;36(1):121-37. PubMed
Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus.
He, X.P., Minichiello, L., Klein, R. & McNamara, J.O.
J Neurosci 2002 Sep 1;22(17):7502-8. PubMed
Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.
Zhang, S.Q., Tsiaras, W.G., Araki, T., Wen, G., Minichiello, L., Klein, R. & Neel, B.G.
Mol Cell Biol 2002 Jun;22(12):4062-72. PubMed
Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons.
Postigo, A., Calella, A.M., Fritzsch, B., Knipper, M., Katz, D., Eilers, A., Schimmang, T., Lewin, G.R., Klein, R. & Minichiello, L.
Genes Dev 2002 Mar 1;16(5):633-45. PubMed
Long-term monitoring of hippocampus-dependent behavior in naturalistic settings: mutant mice lacking neurotrophin receptor TrkB in the forebrain show spatial learning but impaired behavioral flexibility.
Vyssotski, A.L., Dell'Omo, G., Poletaeva, I.I., Vyssotsk, D.L., Minichiello, L., Klein, R., Wolfer, D.P. & Lipp, H.P.
Hippocampus 2002;12(1):27-38. PubMed
Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities.
Fan, G., Egles, C., Sun, Y., Minichiello, L., Renger, J.J., Klein, R., Liu, G. & Jaenisch, R.
Nat Neurosci 2000 Apr;3(4):350-7 PubMed
Shc-binding site in the TrkB receptor is not required for hippocampal long-term potentiation.
Korte, M., Minichiello, L., Klein, R. & Bonhoeffer, T.
Neuropharmacology 2000 Mar 3;39(5):717-24 PubMed
Essential role for TrkB receptors in hippocampus-mediated learning.
Minichiello, L., Korte, M., Wolfer, D., Kuhn, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H.P., Bonhoeffer, T. & Klein, R.
Neuron 1999 Oct;24(2):401-14 PubMed
TrkB and neurotrophin-4 are important for development and maintenance of sympathetic preganglionic neurons innervating the adrenal medulla.
Schober, A., Wolf, N., Huber, K., Hertel, R., Krieglstein, K., Minichiello, L., Kahane, N., Widenfalk, J., Kalcheim, C., Olson, L., Klein, R., Lewin, G.R. & Unsicker, K.
J Neurosci 1998 Sep 15 18(18) 7272-7284 PubMed
Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses.
Minichiello, L., Casagranda, F., Tatche, R.S., Stucky, C.L., Postigo, A., Lewin, G.R., Davies, A.M. & Klein, R.
Neuron 1998 Aug 21(2) 335-345 PubMed
A role for the Ras signalling pathway in synaptic transmission and long- term memory.
Brambilla, R., Gnesutta, N., Minichiello, L., White, G., Roylance, A.J., Herron, C.E., Ramsey, M., Wolfer, D.P., Cestari, V., Rossi-Arnaud, C., Grant, S.G., Chapman, P.F., Lipp, H.P., Sturani, E. & Klein, R.
Nature 1997 Nov 20 390(6657) 281-286 PubMed
Survival of inner ear sensory neurons in trk mutant mice.
Schimmang, T., Alvarez-Bolado, G., Minichiello, L., Vazquez, E., Giraldez, F., Klein, R. & Represa, J.
Mech Dev. 1997 Jun;64(1-2):77-85. PubMed
Reduced acetylcholinesterase (AChE) activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-deficient, but not TrkB-deficient, mice.
Schober, A., Minichiello, L., Keller, M., Huber, K., Layer, P.G., Roig-Lopez, J.L., Garcia-Arraras, J.E., Klein, R. & Unsicker, K.
J Neurosci. 1997 Feb 1;17(3):891-903. PubMed
TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons.
Minichiello, L. & Klein, R.
Genes Dev 1996 Nov 15;10(22):2849-58 PubMed
Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling.
Pinon, L.G., Minichiello, L., Klein, R. & Davies, A.M.
Development 1996 Oct;122(10):3255-61 PubMed
Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons.
Minichiello, L., Piehl, F., Vazquez, E., Schimmang, T., Hokfelt, T., Represa, J. & Klein, R.
Development 1995 Dec;121(12):4067-75 PubMed
Developing inner ear sensory neurons require TrkB and TrkC receptors for innervation of their peripheral targets.
Schimmang, T., Minichiello, L., Vazquez, E., San Jose, I., Giraldez, F., Klein, R. & Represa, J.
Development 1995 Oct;121(10):3381-91 PubMed
Developmental changes in NT3 signalling via TrkA and TrkB in embryonic neurons.
Davies, A.M., Minichiello, L. & Klein, R.
EMBO J. 1995 Sep 15;14(18):4482-9. PubMed