Staff at EMBL

Dr. Claus Nerlov

Visiting Group Leader
Nerlov Group (Visiting)
Joint appointment in the Genome Biology Unit

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

Biography

PhD 1995, the University of Copenhagen, Denmark.
Postdoctoral research at EMBL Heidelberg.
Head of Laboratory of Gene Therapy Research, Copenhagen University Hospital, Denmark.
Group Leader at EMBL since 2001.
Visiting Professor, Stem Cell Center, University of Lund, Sweden, from 2005.

Publications

Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML. Bereshchenko, O., Mancini, E., Moore, S., Bilbao, D., Mansson, R., Luc, S., Grover, A., Jacobsen, S.E., Bryder, D. & Nerlov, C. Cancer Cell. 2009 Nov 6;16(5):390-400. PubMed

C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation. Lopez, R.G., Garcia-Silva, S., Moore, S.J., Bereshchenko, O., Martinez-Cruz, A.B., Ermakova, O., Kurz, E., Paramio, J.M. & Nerlov, C. Nat Cell Biol. 2009 Oct;11(10):1181-90. Epub 2009 Sep 13. PubMed

Targeting a chronic problem: elimination of cancer stem cells in CML. Nerlov, C. EMBO J. 2009 Feb 4;28(3):167-8. PubMed

KEPE--a motif frequently superimposed on sumoylation sites in metazoan chromatin proteins and transcription factors. Diella, F., Chabanis, S., Luck, K., Chica, C., Ramu, C., Nerlov, C. & Gibson, T.J. Bioinformatics. 2009 Jan 1;25(1):1-5. Epub 2008 Nov 24. PubMed

Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen. Hasemann, M.S., Damgaard, I., Schuster, M.B., Theilgaard-Monch, K., Sorensen, A.B., Mrsic, A., Krugers, T., Ylstra, B., Pedersen, F.S., Nerlov, C. & Porse, B.T. Blood. 2008 Apr 15;111(8):4309-21. Epub 2008 Jan 22. PubMed

Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells. Kirstetter, P., Schuster, M.B., Bereshchenko, O., Moore, S., Dvinge, H., Kurz, E., Theilgaard-Monch, K., Mansson, R., Pedersen, T.A., Pabst, T., Schrock, E., Porse, B.T., Jacobsen, S.E., Bertone, P., Tenen, D.G. & Nerlov, C. Cancer Cell. 2008 Apr;13(4):299-310. PubMed

The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes. Nilsson, L., Eden, P., Olsson, E., Mansson, R., Astrand-Grundstrom, I., Strombeck, B., Theilgaard-Monch, K., Anderson, K., Hast, R., Hellstrom-Lindberg, E., Samuelsson, J., Bergh, G., Nerlov, C., Johansson, B., Sigvardsson, M., Borg, A. & Jacobsen, S.E. Blood. 2007 Oct 15;110(8):3005-14. Epub 2007 Jul 6. PubMed

The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control. Nerlov, C. Trends Cell Biol. 2007 Jul;17(7):318-24. Epub 2007 Jul 19. PubMed

Retroviral insertional mutagenesis screen in a C/EBPalpha proliferative genetic background. Hasemann, MS; Sorensen, AB; Pedersen, FS; Nerlov, C; Porse, BT Haematologica - The Hematology Journal 2007 92(Suppl 1)

Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction. Fujimoto, T., Anderson, K., Jacobsen, S.E., Nishikawa, S.I. & Nerlov, C. EMBO J. 2007 May 2;26(9):2361-70. Epub 2007 Apr 12. PubMed

Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes. Anderson, K., Rusterholz, C., Mansson, R., Jensen, C.T., Bacos, K., Zandi, S., Sasaki, Y., Nerlov, C., Sigvardsson, M. & Jacobsen, S.E. Blood. 2007 May 1;109(9):3697-705. Epub 2007 Jan 11. PubMed

Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo. Pedersen, T.A., Bereshchenko, O., Garcia-Silva, S., Ermakova, O., Kurz, E., Mandrup, S., Porse, B.T. & Nerlov, C. EMBO J. 2007 Feb 21;26(4):1081-93. Epub 2007 Feb 8. PubMed

Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription. Calella, A.M., Nerlov, C., Lopez, R.G., Sciarretta, C., von Bohlen Und Halbach, O., Bereshchenko, O. & Minichiello, L. Neural Develop. 2007 Jan 25;2:4. PubMed

Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Kirstetter, P., Anderson, K., Porse, B.T., Jacobsen, S.E. & Nerlov, C. Nat Immunol. 2006 Oct;7(10):1048-56. Epub 2006 Sep 3. PubMed

Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1. Liew, C.W., Rand, K.D., Simpson, R.J., Yung, W.W., Mansfield, R.E., Crossley, M., Proetorius-Ibba, M., Nerlov, C., Poulsen, F.M. & Mackay, J.P. J Biol Chem. 2006 Sep 22;281(38):28296-306. Epub 2006 Jul 20. PubMed

The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo. Porse, B.T., Pedersen, T.A., Hasemann, M.S., Schuster, M.B., Kirstetter, P., Luedde, T., Damgaard, I., Kurz, E., Schjerling, C.K. & Nerlov, C. Mol Cell Biol. 2006 Feb;26(3):1028-37. PubMed

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage. Porse, B.T., Bryder, D., Theilgaard-Monch, K., Hasemann, M.S., Anderson, K., Damgaard, I., Jacobsen, S.E. & Nerlov, C. J Exp Med 2005 Jul 4;202(1):85-96. Epub 2005 Jun 27. PubMed

Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate. Bakri, Y., Sarrazin, S., Mayer, U.P., Tillmanns, S., Nerlov, C., Boned, A. & Sieweke, M.H. Blood 2005 Apr 1;105(7):2707-16. Epub 2004 Dec 14. PubMed

C/EBPalpha mutations in acute myeloid leukaemias. Nerlov, C. Nat Rev Cancer 2004 May;4(5):394-400. PubMed

The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells. D'Alo', F., Johansen, L.M., Nelson, E.A., Radomska, H.S., Evans, E.K., Zhang, P., Nerlov, C. & Tenen, D.G. Blood 2003 Nov 1;102(9):3163-71. Epub 2003 Jul 17. PubMed

Cell cycle inhibition mediated by the outer surface of the C/EBPalpha basic region is required but not sufficient for granulopoiesis. Wang, Q.F., Cleaves, R., Kummalue, T., Nerlov, C. & Friedman, A.D. Oncogene 2003 May 1;22(17):2548-57. PubMed

Disruption of a novel regulatory element in the erythroid-specific promoter of the human PKLR gene causes severe pyruvate kinase deficiency. van Wijk, R., van Solinge, W.W., Nerlov, C., Beutler, E., Gelbart, T., Rijksen, G. & Nielsen, F.C. Blood 2003 Feb 15;101(4):1596-602. PubMed

Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia. Pedersen-Bjergaard, J., Andersen, M.K., Christiansen, D.H. & Nerlov, C. Blood 2002 Mar 15;99(6):1909-12. PubMed

Cooperation between C/EBPalpha TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation. Pedersen, T.A., Kowenz-Leutz, E., Leutz, A. & Nerlov, C. Genes Dev 2001 Dec 1;15(23):3208-16. PubMed

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo. Porse, B.T., Pedersen, T.A., Xu, X., Lindberg, B., Wewer, U.M., Friis-Hansen, L. & Nerlov, C. Cell 2001 Oct 19;107(2):247-58. PubMed

Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors. Querfurth, E., Schuster, M., Kulessa, H., Crispino, J.D., Doderlein, G., Orkin, S.H., Graf, T. & Nerlov, C. Genes Dev 2000 Oct 1;14(19):2515-25. PubMed

GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription. Nerlov, C., Querfurth, E., Kulessa, H. & Graf, T. Blood 2000 Apr 15;95(8):2543-51. PubMed

Distinct C/EBP functions are required for eosinophil lineage commitment and maturation. Nerlov, C., McNagny, K.M., Doderlein, G., Kowenz-Leutz, E. & Graf, T. Genes Dev 1998 Aug 1;12(15):2413-23. PubMed

Distinct C/EBP functions are required for eosinophil lineage commitment and maturation. Nerlov, C., McNagny, K.M., Doderlein, G., Kowenz-Leutz, E. & Graf, T. Genes Dev 1998 Aug 1;12(15):2413-23 PubMed

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors. Nerlov, C. & Graf, T. Genes Dev 1998 Aug 1;12(15):2403-12. PubMed

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors. Nerlov, C. & Graf, T. Genes Dev 1998 Aug 1;12(15):2403-12 PubMed

Regulation of eosinophil-specific gene expression by a C/EBP-Ets complex and GATA-1. McNagny, K.M., Sieweke, M.H., Doderlein, G., Graf, T. & Nerlov, C. EMBO J 1998 Jul 1;17(13):3669-80. PubMed

Regulation of eosinophil-specific gene expression by a C/EBP-Ets complex and GATA-1. McNagny, K.M., Sieweke, M.H., Doderlein, G., Graf, T. & Nerlov, C. EMBO J 1998 Jul 1;17(13):3669-80 PubMed

CCAAT/enhancer binding protein-alpha amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells. Nerlov, C. & Ziff, E.B. EMBO J 1995 Sep 1;14(17):4318-28. PubMed

Three levels of functional interaction determine the activity of CCAAT/enhancer binding protein-alpha on the serum albumin promoter. Nerlov, C. & Ziff, E.B. Genes Dev 1994 Feb 1;8(3):350-62. PubMed

Essential AP-1 and PEA3 binding elements in the human urokinase enhancer display cell type-specific activity. Nerlov, C., Rorth, P., Blasi, F. & Johnsen, M. Oncogene 1991 Sep;6(9):1583-92 PubMed

Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor or phorbol-ester. Rorth, P., Nerlov, C., Blasi, F. & Johnsen, M. Nucleic Acids Res 1990 Sep 11;18(17):5009-17 PubMed