Top image

Staff at EMBL


Dr. Dónal O'Carroll

Group Leader
O'Carroll Group Joint appointment: Genome Biology Unit
Joint appointment: Developmental Biology Unit

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: send a mail


PhD 1999, Research Institute of Molecular Pathology, Vienna.
Postdoctoral research at The Rockefeller University, New York.
Adjunct member of faculty, The Rockefeller University, since 2007.
Group leader at EMBL Monterotondo since 2007.
ERC Investigator since 2012.


Total: 40 publication(s)


Di Giacomo M, Comazzetto S, Sampath SC, Sampath SC, O'Carroll D. (2014)
G9a co-suppresses LINE1 elements in spermatogonia
Epigenetics Chromatin 7 doi:10.1186/1756-8935-7-24
Europe PMC | doi

Grover A, Mancini E, Moore S, Mead AJ, Atkinson D, Rasmussen KD, O'Carroll D, Jacobsen SE, Nerlov C. (2014)
Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate
J. Exp. Med. 211(2):181-188. doi:10.1084/jem.20131189
Europe PMC | doi

Tattikota SG, Rathjen T, McAnulty SJ, Wessels HH, Akerman I, van de Bunt M, Hausser J, Esguerra JL, Musahl A, Pandey AK, You X, Chen W, Herrera PL, Johnson PR, O'Carroll D, Eliasson L, Zavolan M, Gloyn AL, Ferrer J, Shalom-Feuerstein R, Aberdam D, Poy MN. (2014)
Argonaute2 mediates compensatory expansion of the pancreatic β cell
Cell Metab. 19(1):122-134. doi:10.1016/j.cmet.2013.11.015
Europe PMC | doi


Tan CL, Plotkin JL, Venø MT, von Schimmelmann M, Feinberg P, Mann S, Handler A, Kjems J, Surmeier DJ, O'Carroll D, Greengard P, Schaefer A. (2013)
MicroRNA-128 governs neuronal excitability and motor behavior in mice
Science 342(6163):1254-1258. doi:10.1126/science.1244193
Europe PMC | doi

Di Giacomo M, Comazzetto S, Saini H, De Fazio S, Carrieri C, Morgan M, Vasiliauskaite L, Benes V, Enright AJ, O'Carroll D. (2013)
Multiple epigenetic mechanisms and the piRNA pathway enforce LINE1 silencing during adult spermatogenesis
Mol. Cell 50(4):601-608. doi:10.1016/j.molcel.2013.04.026
Europe PMC | doi

O'Carroll D, Schaefer A. (2013)
General principals of miRNA biogenesis and regulation in the brain
Neuropsychopharmacology 38(1):39-54. doi:10.1038/npp.2012.87
Europe PMC | doi


Buza-Vidas N, Cismasiu VB, Moore S, Mead AJ, Woll PS, Lutteropp M, Melchiori L, Luc S, Bouriez-Jones T, Atkinson D, O'Carroll D, Jacobsen SE, Nerlov C. (2012)
Dicer is selectively important for the earliest stages of erythroid development
Blood 120(12):2412-2416. doi:10.1182/blood-2011-10-383653
Europe PMC | doi

Wang D, Zhang Z, O'Loughlin E, Lee T, Houel S, O'Carroll D, Tarakhovsky A, Ahn NG, Yi R. (2012)
Quantitative functions of Argonaute proteins in mammalian development
Genes Dev. 26(7):693-704. doi:10.1101/gad.182758.111
Europe PMC | doi

Mancini E, Sanjuan-Pla A, Luciani L, Moore S, Grover A, Zay A, Rasmussen KD, Luc S, Bilbao D, O'Carroll D, Jacobsen SE, Nerlov C. (2012)
FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors
EMBO J. 31(2):351-365. doi:10.1038/emboj.2011.390
Europe PMC | doi


De Fazio S, Bartonicek N, Di Giacomo M, Abreu-Goodger C, Sankar A, Funaya C, Antony C, Moreira PN, Enright AJ, O'Carroll D. (2011)
The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements
Nature 480(7376):259-263. doi:10.1038/nature10547
Europe PMC | doi

Rasmussen KD, O'Carroll D. (2011)
The miR-144/451eGFP allele, a novel tool for resolving the erythroid potential of hematopoietic precursors
Blood 118(11):2988-2992. doi:10.1182/blood-2011-04-350728
Europe PMC | doi

Muncan V, Heijmans J, Krasinski SD, Büller NV, Wildenberg ME, Meisner S, Radonjic M, Stapleton KA, Lamers WH, Biemond I, van den Bergh Weerman MA, O'Carroll D, Hardwick JC, Hommes DW, van den Brink GR. (2011)
Blimp1 regulates the transition of neonatal to adult intestinal epithelium
Nat Commun 2:452. doi:10.1038/ncomms1463
Europe PMC | doi


Hanina SA, Mifsud W, Down TA, Hayashi K, O'Carroll D, Lao K, Miska EA, Surani MA. (2010)
Genome-wide identification of targets and function of individual MicroRNAs in mouse embryonic stem cells
PLoS Genet. 6(10):e1001163. doi:10.1371/journal.pgen.1001163
Europe PMC | doi

Schaefer A, Im HI, Venø MT, Fowler CD, Min A, Intrator A, Kjems J, Kenny PJ, O'Carroll D, Greengard P. (2010)
Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction
J. Exp. Med. 207(9):1843-1851. doi:10.1084/jem.20100451
Europe PMC | doi

Yang JS, Maurin T, Robine N, Rasmussen KD, Jeffrey KL, Chandwani R, Papapetrou EP, Sadelain M, O'Carroll D, Lai EC. (2010)
Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis
Proc. Natl. Acad. Sci. U.S.A. 107(34):15163-15168. doi:10.1073/pnas.1006432107
Europe PMC | doi

Rasmussen KD, Simmini S, Abreu-Goodger C, Bartonicek N, Di Giacomo M, Bilbao-Cortes D, Horos R, Von Lindern M, Enright AJ, O'Carroll D. (2010)
The miR-144/451 locus is required for erythroid homeostasis
J. Exp. Med. 207(7):1351-1358. doi:10.1084/jem.20100458
Europe PMC | doi

Andersson T, Rahman S, Sansom SN, Alsiö JM, Kaneda M, Smith J, O'Carroll D, Tarakhovsky A, Livesey FJ. (2010)
Reversible block of mouse neural stem cell differentiation in the absence of dicer and microRNAs
PLoS ONE 5(10):e13453. doi:10.1371/journal.pone.0013453
Europe PMC | doi


Yi R, Pasolli HA, Landthaler M, Hafner M, Ojo T, Sheridan R, Sander C, O'Carroll D, Stoffel M, Tuschl T, Fuchs E. (2009)
DGCR8-dependent microRNA biogenesis is essential for skin development
Proc. Natl. Acad. Sci. U.S.A. 106(2):498-502. doi:10.1073/pnas.0810766105
Europe PMC | doi

Kaneda M, Tang F, O'Carroll D, Lao K, Surani MA. (2009)
Essential role for Argonaute2 protein in mouse oogenesis
Epigenetics Chromatin 2(1):9. doi:10.1186/1756-8935-2-9
Europe PMC | doi


Liston A, Lu LF, O'Carroll D, Tarakhovsky A, Rudensky AY. (2008)
Dicer-dependent microRNA pathway safeguards regulatory T cell function
J. Exp. Med. 205(9):1993-2004. doi:10.1084/jem.20081062
Europe PMC | doi

Tang F, Hajkova P, O'Carroll D, Lee C, Tarakhovsky A, Lao K, Surani MA. (2008)
MicroRNAs are tightly associated with RNA-induced gene silencing complexes in vivo
Biochem. Biophys. Res. Commun. 372(1):24-29. doi:10.1016/j.bbrc.2008.04.137
Europe PMC | doi

Hayashi K, Chuva de Sousa Lopes SM, Kaneda M, Tang F, Hajkova P, Lao K, O'Carroll D, Das PP, Tarakhovsky A, Miska EA, Surani MA. (2008)
MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis
PLoS ONE 3(3) doi:10.1371/journal.pone.0001738
Europe PMC | doi


O'Carroll D, Mecklenbrauker I, Das PP, Santana A, Koenig U, Enright AJ, Miska EA, Tarakhovsky A. (2007)
A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway
Genes Dev. 21(16):1999-2004. doi:10.1101/gad.1565607
Europe PMC | doi

Schaefer A, O'Carroll D, Tan CL, Hillman D, Sugimori M, Llinas R, Greengard P. (2007)
Cerebellar neurodegeneration in the absence of microRNAs
J. Exp. Med. 204(7):1553-1558. doi:10.1084/jem.20070823
Europe PMC | doi

Tang F, Kaneda M, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA. (2007)
Maternal microRNAs are essential for mouse zygotic development
Genes Dev. 21(6):644-648. doi:10.1101/gad.418707
Europe PMC | doi


Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, Fuchs E. (2006)
Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland
Cell 126(3):597-609. doi:10.1016/j.cell.2006.06.048
Europe PMC | doi

Yi R, O'Carroll D, Pasolli HA, Zhang Z, Dietrich FS, Tarakhovsky A, Fuchs E. (2006)
Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs
Nat. Genet. 38(3):356-362. doi:10.1038/ng1744
Europe PMC | doi

Tang F, Hajkova P, Barton SC, O'Carroll D, Lee C, Lao K, Surani MA. (2006)
220-plex microRNA expression profile of a single cell
Nat Protoc 1(3):1154-1159. doi:10.1038/nprot.2006.161
Europe PMC | doi

Ohinata Y, Seki Y, Payer B, O'Carroll D, Surani MA, Saitou M. (2006)
Germline recruitment in mice: a genetic program for epigenetic reprogramming
Ernst Schering Res. Found. Workshop (60):143-174. doi:10.1007/3-540-31437-7_11
Europe PMC | doi


Saitou M, Payer B, O'Carroll D, Ohinata Y, Surani MA. (2005)
Blimp1 and the emergence of the germ line during development in the mouse
Cell Cycle 4(12):1736-1740.
Europe PMC

Ohinata Y, Payer B, O'Carroll D, Ancelin K, Ono Y, Sano M, Barton SC, Obukhanych T, Nussenzweig M, Tarakhovsky A, Saitou M, Surani MA. (2005)
Blimp1 is a critical determinant of the germ cell lineage in mice
Nature 436(7048):207-213. doi:10.1038/nature03813
Europe PMC | doi


Lagger G, O'Carroll D, Rembold M, Khier H, Tischler J, Weitzer G, Schuettengruber B, Hauser C, Brunmeir R, Jenuwein T, Seiser C. (2002)
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
EMBO J. 21(11):2672-2681. doi:10.1093/emboj/21.11.2672
Europe PMC | doi

Peters AH, Mermoud JE, O'Carroll D, Pagani M, Schweizer D, Brockdorff N, Jenuwein T. (2002)
Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin
Nat. Genet. 30(1):77-80. doi:10.1038/ng789
Europe PMC | doi


Peters AH, O'Carroll D, Scherthan H, Mechtler K, Sauer S, Schöfer C, Weipoltshammer K, Pagani M, Lachner M, Kohlmaier A, Opravil S, Doyle M, Sibilia M, Jenuwein T. (2001)
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability
Cell 107(3):323-337. doi:10.1016/s0092-8674(01)00542-6
Europe PMC | doi

Nielsen SJ, Schneider R, Bauer UM, Bannister AJ, Morrison A, O'Carroll D, Firestein R, Cleary M, Jenuwein T, Herrera RE, Kouzarides T. (2001)
Rb targets histone H3 methylation and HP1 to promoters
Nature 412(6846):561-565. doi:10.1038/35087620
Europe PMC | doi

O'Carroll D, Erhardt S, Pagani M, Barton SC, Surani MA, Jenuwein T. (2001)
The polycomb-group gene Ezh2 is required for early mouse development
Mol. Cell. Biol. 21(13):4330-4336. doi:10.1128/mcb.21.13.4330-4336.2001
Europe PMC | doi

Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T. (2001)
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Nature 410(6824):116-120. doi:10.1038/35065132
Europe PMC | doi


O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei MG, Denny P, Brown SD, Schweizer D, Jenuwein T. (2000)
Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression
Mol. Cell. Biol. 20(24):9423-9433. doi:10.1128/mcb.20.24.9423-9433.2000
Europe PMC | doi

Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD, Jenuwein T. (2000)
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Nature 406(6796):593-599. doi:10.1038/35020506
Europe PMC | doi


Laible G, Haynes AR, Lebersorger A, O'Carroll D, Mattei MG, Denny P, Brown SD, Jenuwein T. (1999)
The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse chromosomes 11 and 6
Mamm. Genome 10(3):311-314. doi:10.1007/s003359900993
Europe PMC | doi