Staff at EMBL

Full CV

Biography

PhD 1981, Harvard Medical School, USA
Postdoctoral research at the National Cancer Institute, USA
Assistant Professor, Boston University Medical Center, USA
Associate Professor, Massachusetts General Hospital, USA
Group Leader and Head of EMBL Monterotondo Outstation since 2001
Inaugural Professor-at-Large, Institute of Advanced Studies, U. of Western Australia 2001 - 2003
Visiting Professor, University of Western Australia 2003 -
Professor of Cardiovascular Science, Imperial College London 2005 -
Founding Director, Australian Regenerative Medicine Institute, Monash U., Melbourne 2007 -

Publications

Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice. Semenova, E., Koegel, H., Hasse, S., Klatte, J.E., Slonimsky, E., Bilbao, D., Paus, R., Werner, S. & Rosenthal, N. Am J Pathol. 2008 Nov;173(5):1295-310. Epub 2008 Oct 2. PubMed

Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction. Burchfield, J.S., Iwasaki, M., Koyanagi, M., Urbich, C., Rosenthal, N., Zeiher, A.M. & Dimmeler, S. Circ Res. 2008 Jul 18;103(2):203-11. Epub 2008 Jun 19. PubMed

NF-kappaB signaling in skeletal muscle: prospects for intervention in muscle diseases. Mourkioti, F. & Rosenthal, N. J Mol Med. 2008 Jul;86(7):747-59. Epub 2008 Feb 2. PubMed

Derive and conquer: sourcing and differentiating stem cells for therapeutic applications. Klimanskaya, I., Rosenthal, N. & Lanza, R. Nat Rev Drug Discov. 2008 Feb;7(2):131-42. PubMed

Follistatin gene expression in heart failure and myocardial recovery following LVAD combination therapy. Lara-Pezzi, E; Felkin, LE; Sarathchandra, P; George, R; Hall, JL; Yacoub, MH; Rosenthal, N.; Birks, EJ; Barton, PJ Journal of Heart and Lung Transplantation 2008 27(2) S220

A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration. Lara-Pezzi, E., Winn, N., Paul, A., McCullagh, K., Slominsky, E., Santini, M.P., Mourkioti, F., Sarathchandra, P., Fukushima, S., Suzuki, K. & Rosenthal, N. J Cell Biol. 2007 Dec 17;179(6):1205-18. PubMed

The mouse ascending: perspectives for human-disease models. Rosenthal, N. & Brown, S. Nat Cell Biol. 2007 Sep;9(9):993-9. PubMed

ROCK2 and its alternatively spliced isoform ROCK2m positively control the maturation of the myogenic program. Pelosi, M., Marampon, F., Zani, B.M., Prudente, S., Perlas, E., Caputo, V., Cianetti, L., Berno, V., Narumiya, S., Kang, S.W., Musaro, A. & Rosenthal, N. Mol Cell Biol. 2007 Sep;27(17):6163-76. Epub 2007 Jul 2. PubMed

Phenostat: visualization and statistical tool for analysis of phenotyping data. Reuveni, E., Carola, V., Banchaabouchi, M.A., Rosenthal, N., Hancock, J.M. & Gross, C. Mamm Genome. 2007 Aug 3;. PubMed

Immune response to stem cells and strategies to induce tolerance. Batten, P., Rosenthal, N.A. & Yacoub, M.H. Philos Trans R Soc Lond B Biol Sci. 2007 Aug 29;362(1484):1343-56. PubMed

Enhancing repair of the mammalian heart. Santini, M.P., Tsao, L., Monassier, L., Theodoropoulos, C., Carter, J., Lara-Pezzi, E., Slonimsky, E., Salimova, E., Delafontaine, P., Song, Y.H., Bergmann, M., Freund, C., Suzuki, K. & Rosenthal, N. Circ Res. 2007 Jun 22;100(12):1732-40. Epub 2007 May 24. PubMed

Identification of novel peptide hormones in the human proteome by hidden Markov model screening. Mirabeau, O., Perlas, E., Severini, C., Audero, E., Gascuel, O., Possenti, R., Birney, E., Rosenthal, N. & Gross, C. Genome Res. 2007 Mar;17(3):320-7. Epub 2007 Feb 6. PubMed

Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines. Pelosi, L., Giacinti, C., Nardis, C., Borsellino, G., Rizzuto, E., Nicoletti, C., Wannenes, F., Battistini, L., Rosenthal, N., Molinaro, M. & Musaro, A. FASEB J. 2007 Jan 30;. PubMed

The neuroprotective effects of a locally acting IGF-1 isoform. Musaro, A., Dobrowolny, G. & Rosenthal, N. Exp Gerontol. 2007 Jan-Feb;42(1-2):76-80. Epub 2006 Jun 19. PubMed

Overexpression of mlGF-1 in proliferating keratinocytes accelerates hair follicle formation and cycling and improves wound healing in mice. Semenova, E; Werner, S; Koegel, H; Pastore, S; Hasse, S; Paus, R; Rosenthal, N. Journal or Investigative Dermatology April 2007 127 Supl 1

Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration. Mourkioti, F., Kratsios, P., Luedde, T., Song, Y.H., Delafontaine, P., Adami, R., Parente, V., Bottinelli, R., Pasparakis, M. & Rosenthal, N. J Clin Invest. 2006 Nov 1;116(11):2945-2954. PubMed

Signalling pathways in cardiac regeneration. Santini MP, Winn N, Rosenthal N. Novartis Found Symp. 2006

NF-kappa B signalling in muscle regeneration Rosenthal, N; Mourkioti, F; Lara-Pezzi, E; Pasparakis, M FEBS Journal June 2006 (273)

Growth factor enhancement of cardiac regeneration. Rosenthal, N., Santini, M.P. & Musaro, A. Cell Transplant. 2006;15 Suppl 1:S41-5. PubMed

Conference of the International Society of Differentiation Rosenthal, N. DIFFERENTIATION October 2006 74(8)

Enhancing mammalian regeneration Rosenthal, N. DIFFERENTIATION October 2006 74(8)

Growth factor enhancement of mammalian regeneration. Rosenthal, N. Kidney Int 2005 Nov;68(5):1965-6. PubMed

IGF-1, inflammation and stem cells: interactions during muscle regeneration. Mourkioti, F. & Rosenthal, N. Trends Immunol 2005 Oct;26(10):535-542. PubMed

Transgenic overexpression of locally acting insulin-like growth factor-1 inhibits ubiquitin-mediated muscle atrophy in chronic left-ventricular dysfunction. Schulze, P.C., Fang, J., Kassik, K.A., Gannon, J., Cupesi, M., MacGillivray, C., Lee, R.T. & Rosenthal, N. Circ Res 2005 Sep 2;97(5):418-26. Epub 2005 Jul 28. PubMed

Vasopressin-dependent myogenic cell differentiation is mediated by both Ca2+/calmodulin-dependent kinase and calcineurin pathways. Scicchitano, B.M., Spath, L., Musaro, A., Molinaro, M., Rosenthal, N., Nervi, C. & Adamo, S. Mol Biol Cell 2005 Aug;16(8):3632-41. Epub 2005 Jun 1. PubMed

Youthful prospects for human stem-cell therapy. In another few decades, revised attitudes toward stem cells could lead to disease prevention and life extension. Rosenthal, N. EMBO Rep. 2005 Jul;6 Spec No:S30-4. PubMed

Insulin-like growth factor I-mediated skeletal muscle hypertrophy is characterized by increased mTOR-p70S6K signaling without increased Akt phosphorylation. Song, Y.H., Godard, M., Li, Y., Richmond, S.R., Rosenthal, N. & Delafontaine, P. J Investig Med 2005 Apr;53(3):135-42. PubMed

Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting. Song, Y.H., Li, Y., Du, J., Mitch, W.E., Rosenthal, N. & Delafontaine, P. J Clin Invest 2005 Feb;115(2):451-8. PubMed

Reconciling data from transgenic mice that overexpress IGF-I specifically in skeletal muscle. Shavlakadze, T., Winn, N., Rosenthal, N. & Grounds, M.D. Growth Horm IGF Res 2005 Feb;15(1):4-18. Epub 2005 Jan 21. PubMed

Human hepatocytes in mice receiving pre-immune injection with human cord blood cells. Turrini, P., Monego, G., Gonzalez, J., Cicuzza, S., Bonanno, G., Zelano, G., Rosenthal, N., Paonessa, G., Laufer, R. & Padron, J. Biochem Biophys Res Commun 2005 Jan 7;326(1):66-73. PubMed

Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model. Dobrowolny, G., Giacinti, C., Pelosi, L., Nicoletti, C., Winn, N., Barberi, L., Molinaro, M., Rosenthal, N. & Musaro, A. J Cell Biol 2005 Jan 17;168(2):193-9. PubMed

The European dimension for the mouse genome mutagenesis program. Auwerx, J., Avner, P., Baldock, R., Ballabio, A., Balling, R., Barbacid, M., Berns, A., Bradley, A., Brown, S., Carmeliet, P., Chambon, P., Cox, R., Davidson, D., Davies, K., Duboule, D., Forejt, J., Granucci, F., Hastie, N., de Angelis, M.H., Jackson, I., Kioussis, D., Kollias, G., Lathrop, M., Lendahl, U., Malumbres, M., von Melchner, H., Muller, W., Partanen, J., Ricciardi-Castagnoli, P., Rigby, P., Rosen, B., Rosenthal, N., Skarnes, B., Stewart, A.F., Thornton, J., Tocchini-Valentini, G., Wagner, E., Wahli, W. & Wurst, W. Nat Genet 2004 Sep;36(9):925-7. PubMed

The stem cell challenge. Lanza, R. & Rosenthal, N. Sci Am 2004 Jun;290(6):92-9. PubMed

Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1. Musaro, A., Giacinti, C., Borsellino, G., Dobrowolny, G., Pelosi, L., Cairns, L., Ottolenghi, S., Cossu, G., Bernardi, G., Battistini, L., Molinaro, M. & Rosenthal, N. Proc Natl Acad Sci U S A 2004 Feb 3;101(5):1206-10. Epub 2004 Jan 26. PubMed

Targeted expression of insulin-like growth factor-1 reduces early myofiber necrosis in dystrophic mdx mice. Shavlakadze, T., White, J., Hoh, J.F., Rosenthal, N. & Grounds, M.D. Mol. Ther. 2004 10 829-843

Stem cells and the regenerating heart. Rosenthal, N. & Santini, M.P. In "Stem Cell Handbook" Elsevier, 2004

A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field. Hochgreb, T., Linhares, V.L., Menezes, D.C., Sampaio, A.C., Yan, C.Y., Cardoso, W.V., Rosenthal, N. & Xavier-Neto, J. Development 2003 Nov;130(22):5363-74. Epub 2003 Sep 16. PubMed

Prometheus's vulture and the stem-cell promise. Rosenthal, N. N Engl J Med 2003 Jul 17;349(3):267-74. PubMed

Developmental basis of evolutionary digit loss in the Australian lizard Hemiergis. Shapiro, M.D., Hanken, J. & Rosenthal, N. J Exp Zoolog Part B Mol Dev Evol 2003 Jun 15;297(1):48-56. PubMed

Normal female sexual development requires neuregulin-erbB receptor signaling in hypothalamic astrocytes. Prevot, V., Rio, C., Cho, G.J., Lomniczi, A., Heger, S., Neville, C.M., Rosenthal, N.A., Ojeda, S.R. & Corfas, G. J Neurosci 2003 Jan 1;23(1):230-9. PubMed

Machinations of the marrow. Rosenthal, N. J Clin Invest 2003 Jan;111(1):29-30. PubMed

Gene therapy for cardiac cachexia? Rosenthal, N. & Musaro, A. Int J Cardiol 2002 Sep;85(1):185-91. PubMed

Taking stock of our models: the function and future of stock centres. Rosenthal, N. & Ashburner, M. Nat Rev Genet 2002 Sep;3(9):711-7. PubMed

The role of stem cells in skeletal and cardiac muscle repair. Grounds, M.D., White, J.D., Rosenthal, N. & Bogoyevitch, M.A. J Histochem Cytochem 2002 May;50(5):589-610. PubMed

Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice. Barton, E.R., Morris, L., Musaro, A., Rosenthal, N. & Sweeney, H.L. J Cell Biol 2002 Apr 1;157(1):137-48. PubMed

Targeted deletion of the MLC1f/3f downstream enhancer results in precocious MLC expression and mesoderm ablation. Jiang, P., Song, J., Gu, G., Slonimsky, E., Li, E. & Rosenthal, N. Dev Biol 2002 Mar 15;243(2):281-93. PubMed

Different modes of hypertrophy in skeletal muscle fibers. Paul, A.C. & Rosenthal, N. J Cell Biol 2002 Feb 18;156(4):751-60. PubMed

The role of Insulin-like Growth Factor-1 isoforms in the physiopathology of skeletal muscle. Musaro, A. & Rosenthal, N. Current Genomics 2002 3(3) 149-162

Retinoid signaling and cardiac anteroposterior segmentation. Xavier-Neto, J., Rosenthal, N., Silva, F.A., Matos, T.G., Hochgreb, T. & Linhares, V.L. Genesis 2001 Nov;31(3):97-104. PubMed

High hopes for the heart. Rosenthal, N. N Engl J Med 2001 Jun 7;344(23):1785-7. PubMed

Helping the heart to heal with stem cells. Rosenthal, N. & Tsao, L. Nat Med 2001 Apr;7(4):412-3. PubMed

Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Bruneau, B.G., Bao, Z.Z., Fatkin, D., Xavier-Neto, J., Georgakopoulos, D., Maguire, C.T., Berul, C.I., Kass, D.A., Kuroski-de Bold, M.L., de Bold, A.J., Conner, D.A., Rosenthal, N., Cepko, C.L., Seidman, C.E. & Seidman, J.G. Mol Cell Biol 2001 Mar;21(5):1730-6. PubMed

Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Musaro, A., McCullagh, K., Paul, A., Houghton, L., Dobrowolny, G., Molinaro, M., Barton, E.R., Sweeney, H.L. & Rosenthal, N. Nat Genet 2001 Feb;27(2):195-200. PubMed

From the bottom of the heart: anteroposterior decisions in cardiac muscle differentiation. Rosenthal, N. & Xavier-Neto, J. Curr Opin Cell Biol 2000 Dec;12(6):742-6. PubMed

Sequential programs of retinoic acid synthesis in the myocardial and epicardial layers of the developing avian heart. Xavier-Neto, J., Shapiro, M.D., Houghton, L. & Rosenthal, N. Dev Biol 2000 Mar 1;219(1):129-41. PubMed

Revisiting calcineurin and human heart failure. Tsao, L., Neville, C., Musaro, A., McCullagh, K.J. & Rosenthal, N. Nat Med 2000 Jan;6(1):2-3. PubMed

An E box comprises a positional sensor for regional differences in skeletal muscle gene expression and methylation. Ceccarelli, E., McGrew, M.J., Nguyen, T., Grieshammer, U., Horgan, D., Hughes, S.H. & Rosenthal, N. Dev Biol 1999 Sep 1;213(1):217-29. PubMed

IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1. Musaro, A., McCullagh, K.J., Naya, F.J., Olson, E.N. & Rosenthal, N. Nature 1999 Aug 5;400(6744):581-5. PubMed

A retinoic acid-inducible transgenic marker of sino-atrial development in the mouse heart. Xavier-Neto, J., Neville, C.M., Shapiro, M.D., Houghton, L., Wang, G.F., Nikovits W, J.r, Stockdale, F.E. & Rosenthal, N. Development 1999 Jun;126(12):2677-87. PubMed

Maturation of the myogenic program is induced by postmitotic expression of insulin-like growth factor I. Musaro, A. & Rosenthal, N. Mol Cell Biol 1999 Apr;19(4):3115-24. PubMed

Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function. Barton-Davis, E.R., Shoturma, D.I., Musaro, A., Rosenthal, N. & Sweeney, H.L. Proc Natl Acad Sci U S A 1998 Dec 22;95(26):15603-7. PubMed

Dynamic patterns of retinoic acid synthesis and response in the developing mammalian heart. Moss, J.B., Xavier-Neto, J., Shapiro, M.D., Nayeem, S.M., McCaffery, P., Drager, U.C. & Rosenthal, N. Dev Biol 1998 Jul 1;199(1):55-71. PubMed