Scientists across EMBL use computers to analyse a wide range of different biological, medical, environmental and ecological data. These bioinformatics activities include, but are not limited to: whole genome analyses, metagenomics, analysis of gene, protein, and metabolic networks, structural biology, protein and nucleotide sequence analysis and large scale cell imaging. There are also activities in instrumentation and engineering software development, especially at the Grenoble and Hamburg outstations.

While some research groups focus almost exclusively on computational research, there are also many groups at EMBL which combine experimental and computational analysis. Bioinformatics is an important part of the work done by the EMBL groups listed below; in addition to these groups, EMBL-EBI includes many labs dedicated to bioinformatics research and service provision.

Bars at the bottom of each image indicate the proportion of that group's activities taken up by bioinformatics.

Gibson Team

Gibson Team
Biological sequence analysis

The Gibson team investigates protein sequence interactions, undertakes computational analyses of macromolecules, and develops tools to enhance sequence analysis research.

Huber Group

Huber Group
Multi-omics and statistical computing

The Huber group develops large-scale statistical models that integrate genomic, molecular and phenotypic data to understand the variations between individuals in health and disease.

Bork Group

Bork Group
Deciphering function and evolution of biological systems

By analysing and comparing complex molecular data, the Bork group predicts function, gains insights into evolution, and makes connections between genes, organisms and ecosystems.

Patil Group

Patil Group (Visiting)
Architecture and regulation of metabolic networks

The Patil group uses a combination of modelling, bioinformatics, and experimental approaches to study metabolic networks and how they are controlled.

Korbel Group

Korbel Group
From genomic variation to molecular mechanism

The Korbel group combines experimental and computational biology to decipher the function and origin of genetic variation with a particular focus on heritable genomic structural variants (SVs) and such occurring in cancer.

Beck Group (Visiting)
Structure and function of large molecular assemblies

Research in the Beck group combines biochemical approaches, proteomics and cryo-electron microscopy to study large macromolecular assemblies.

Hiiragi Group (Visiting)
Symmetry breaking and self-organisation

Looking at the molecular, cellular and systems levels, the Hiiragi group studies how, early in mammal development, the embryo is shaped from a spherical mass of cells.

Steinmetz Group
Systems genetics and precision health

The Steinmetz group bridges diverse domains of genome science, from deciphering the structure and function of genomes to the application of these insights in understanding diseases.

Svergun Group
Small-angle X-ray scattering from macromolecular solutions

The Svergun group places special emphasis on hybrid methods combining SAXS with X-ray crystallography, NMR spectroscopy, and electron microscopy to improve the resolution and cross-validate structural models. 

Ellenberg Group
Cell division and nuclear organisation

The Ellenberg group studies how cells divide and organise in mitosis and meiosis, where errors can lead to problems such as cancer and infertility.

Furlong Group
Genome regulation and topology during embryonic development

The Furlong group dissects fundamental principles of transcriptional regulation, and how that drives cell fate decisions during development, focusing on functional and organisational properties of the genome.

Gavin Group (Visiting)
Biomolecular networks in health and disease

The Gavin group focuses on detailed and systematic charting of cellular networks and circuitry at molecular levels in time and space.  

Barabas Group (Visiting)
Mechanisms, regulation and application of mobile DNA

The Barabas group uses structural and molecular biology approaches to investigate how DNA rearrangements are carried out and regulated, with the ultimate goal of facilitating their applications in research and therapy.

Genomics Core Facility

GeneCore is the in-house genomics service centre at EMBL equipped with state-of-the-art technologies required for functional genomics analyses and operated by highly qualified staff.  

Typas Group
Systems microbiology

The Typas group develops and utilises high-throughput methods to study the cellular networks of different species of bacteria, and how these bacteria interact with the environment and with each other. 

Arendt Group
Evolution of the nervous system in Bilateria

By studying and comparing simple marine organisms, the Arendt group looks to understand the origin and evolution of our central nervous system.

Hentze Group
RNA biology, metabolism and molecular medicine

The Hentze group combines biochemical and systems level approaches to investigate the connections between gene expression, cell metabolism, and their role in human disease. 

Leptin Group
Cell shape and morphogenesis: subcellular and supracellular mechanisms

The Leptin group studies the mechanisms and forces that determine cell shape in Drosophila and uses the zebrafish to analyse innate immune signalling.