Future Seminars
Seminar Colour Guide:
| Career Event | Thursday, 30 September 2021, 11:00Careers & recruiter talk from NovoNordiskJo Billetoft, Stem Cell CMC & Manufacturing Department, DenmarkSofia Håkansson Buch, Stem Cell CMC & Manufacturing Department, DenmarkHost: EMBL Fellows’ Career ServiceVirtual, Virtual |
| Planetary Biology Lectures | Monday, 18 October 2021, 14:00Planetary Scale Metabolomics - Linking Chemotypes to EcosystemsDaniel Petras, University of Tübingen, GermanyVirtual, Virtual Abstract: https://embl-org.zoom.us/j/93608179765?pwd=dU1aTERLdm5YVEl5MlJ4VVJNMGNrQT09
Meeting ID: 936 0817 9765
Passcode: PBLS |
| Planetary Biology Lectures | Thursday, 18 November 2021, 16:00To be announcedMark Bailey, UK Centre for Ecology & Hydrology, United KingdomVirtual, Virtual Abstract: https://embl-org.zoom.us/j/93608179765?pwd=dU1aTERLdm5YVEl5MlJ4VVJNMGNrQT09
Meeting ID: 936 0817 9765
Passcode: PBLS |
| EMBL - Sapienza Lecture | |
| External Faculty Speaker | |
| External Faculty Speaker | |
| External Faculty Speaker | Friday, 10 December 2021, 11:00The Awakening of the 3D GenomeJuanma Vaquerizas, MRC London Institute of Medical Sciences
London, United KingdomHost: Ana BoskovicVirtual seminar, EMBL Rome Abstract: The three-dimensional organisation of the genome plays a fundamental role in the regulation of gene expression. However, despite the recent characterisation of regulators associated to this organisation, we currently lack an understanding of how chromatin conformation is first established during development, and the molecular mechanisms that drive this process.
In the first part of my talk, I will focus on recent work in which, using Drosophila as a model system, we investigated chromatin conformation dynamics in embryos at different time points during early embryonic development. Using genetic tools and single-cell technologies, we evaluate the level of heterogeneity in chromatin conformation across different tissues at sub-kilobase resolution. This allows us to unveil that the three-dimensional organisation of chromatin at this developmental stage is likely to serve as an architectural framework to enable transcriptional regulation.
In the second part of my talk, I will turn into mammalian early embryonic development. In particular, I will focus on transposable elements, which are highly abundant in eukaryotic genomes and have been recently associated with the process of zygotic genome activation. Using genome-wide chromatin conformation maps, I will show how the Murine Endogenous Retroviral Element (MuERV-L/MERVL) family of transposable elements drives 3D chromatin reorganisation in 2-cell-embryo-like cells as well as in the mouse 2-cell embryo. This reorganisation involves the emergence of hundreds of TAD boundaries across the genome and it is associated to the upregulation of directional transcription from MERVL, which results in the activation of a subset of 2-cell embryo genes. These results have important implications for our understanding of how nuclear organisation emerges during zygotic genome activation in mammals, and how this organisation can be influenced by repetitive elements during early embryonic development. |
| EMBL Distinguished Visitor Lecture | |
| EMBL - Sapienza Lecture | |
| EMBL Distinguished Visitor Lecture | |
| EMBL - Sapienza Lecture | Friday, 7 October 2022, 11:00To be announcedTracy Bale, Center for Epigenetic Research in Child Health and Brain Development
University of Maryland School of Medicine
Baltimore, MD, USAHost: Cornelius Gross and Andrea MeleSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Rome |
| EMBL - Sapienza Lecture | Friday, 21 October 2022, 11:00To be announcedTony Kouzarides , Milner Therapeutics Institute and Gurdon Institute
University of Cambridge
Cambridge, United KingdomHost: Mathieu Boulard / Irene BozzoniSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Rome |