EMBL Rome, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00015 Monterotondo (RM), Italy

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Biography

  • PhD 2010, University of Edinburgh.
    Postdoctoral research at Gurdon Institute, University of Cambridge.
    Group leader at EMBL since 2016. Joint Appointment with the Genome Biology Unit.

Publications

Total: 19 publication(s)

2017

Huang Y, Kim JK, Do DV, Lee C, Penfold CA, Zylicz JJ, Marioni JC, Hackett JA, Surani MA. (2017)

STELLA modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition.

Elife 6:1-23. doi: 10.7554/elife.22345
Europe PMC | doi


2015

Tang WW, Dietmann S, Irie N, Leitch HG, Floros VI, Bradshaw CR, Hackett JA, Chinnery PF, Surani MA. (2015)

A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development.

Cell 161(6):1453-1467. doi: 10.1016/j.cell.2015.04.053
Europe PMC | doi

Zylicz JJ, Dietmann S, Günesdogan U, Hackett JA, Cougot D, Lee C, Surani MA. (2015)

Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development.

Elife 4 doi: 10.7554/elife.09571
Europe PMC | doi


2014

Kim S, Günesdogan U, Zylicz JJ, Hackett JA, Cougot D, Bao S, Lee C, Dietmann S, Allen GE, Sengupta R, Surani MA. (2014)

PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos.

Mol. Cell 56(4):564-579. doi: 10.1016/j.molcel.2014.10.003
Europe PMC | doi

Hackett JA, Surani MA. (2014)

Regulatory principles of pluripotency: from the ground state up.

Cell Stem Cell 15(4):416-430. doi: 10.1016/j.stem.2014.09.015
Europe PMC | doi

Singer ZS, Yong J, Tischler J, Hackett JA, Altinok A, Surani MA, Cai L, Elowitz MB. (2014)

Dynamic heterogeneity and DNA methylation in embryonic stem cells.

Mol. Cell 55(2):319-331. doi: 10.1016/j.molcel.2014.06.029
Europe PMC | doi


2013

Hackett JA, Dietmann S, Murakami K, Down TA, Leitch HG, Surani MA. (2013)

Synergistic mechanisms of DNA demethylation during transition to ground-state pluripotency.

Stem Cell Reports 1(6):518-531. doi: 10.1016/j.stemcr.2013.11.010
Europe PMC | doi

Grabole N, Tischler J, Hackett JA, Kim S, Tang F, Leitch HG, Magnúsdóttir E, Surani MA. (2013)

Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation.

EMBO Rep. 14(7):629-637. doi: 10.1038/embor.2013.67
Europe PMC | doi

Hackett JA, Surani MA. (2013)

Beyond DNA: programming and inheritance of parental methylomes.

Cell 153(4):737-739. doi: 10.1016/j.cell.2013.04.044
Europe PMC | doi

Hackett JA, Sengupta R, Zylicz JJ, Murakami K, Lee C, Down TA, Surani MA. (2013)

Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine.

Science 339(6118):448-452. doi: 10.1126/science.1229277
Europe PMC | doi

Hackett JA, Surani MA. (2013)

DNA methylation dynamics during the mammalian life cycle.

Philos. Trans. R. Soc. Lond., B, Biol. Sci. 368(1609) doi: 10.1098/rstb.2011.0328
Europe PMC | doi


2012

Hackett JA, Reddington JP, Nestor CE, Dunican DS, Branco MR, Reichmann J, Reik W, Surani MA, Adams IR, Meehan RR. (2012)

Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline.

Development 139(19):3623-3632. doi: 10.1242/dev.081661
Europe PMC | doi

Hackett JA, Zylicz JJ, Surani MA. (2012)

Parallel mechanisms of epigenetic reprogramming in the germline.

Trends Genet. 28(4):164-174. doi: 10.1016/j.tig.2012.01.005
Europe PMC | doi

Thomson JP, Lempiäinen H, Hackett JA, Nestor CE, Müller A, Bolognani F, Oakeley EJ, Schübeler D, Terranova R, Reinhardt D, Moggs JG, Meehan RR. (2012)

Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome.

Genome Biol. 13(10) doi: 10.1186/gb-2012-13-10-r93
Europe PMC | doi


2010

Meng HX, Hackett JA, Nestor C, Dunican DS, Madej M, Reddington JP, Pennings S, Harrison DJ, Meehan RR. (2010)

Apoptosis and DNA methylation.

Cancers (Basel) 3(2):1798-1820. doi: 10.3390/cancers3021798
Europe PMC | doi


2009

Ruzov A, Hackett JA, Prokhortchouk A, Reddington JP, Madej MJ, Dunican DS, Prokhortchouk E, Pennings S, Meehan RR. (2009)

The interaction of xKaiso with xTcf3: a revised model for integration of epigenetic and Wnt signalling pathways.

Development 136(5):723-727. doi: 10.1242/dev.025577
Europe PMC | doi

Ruzov A, Savitskaya E, Hackett JA, Reddington JP, Prokhortchouk A, Madej MJ, Chekanov N, Li M, Dunican DS, Prokhortchouk E, Pennings S, Meehan RR. (2009)

The non-methylated DNA-binding function of Kaiso is not required in early Xenopus laevis development.

Development 136(5):729-738. doi: 10.1242/dev.025569
Europe PMC | doi


2008

Sanford JR, Coutinho P, Hackett JA, Wang X, Ranahan W, Caceres JF. (2008)

Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF.

PLoS ONE 3(10) doi: 10.1371/journal.pone.0003369
Europe PMC | doi

Dunican DS, Ruzov A, Hackett JA, Meehan RR. (2008)

xDnmt1 regulates transcriptional silencing in pre-MBT Xenopus embryos independently of its catalytic function.

Development 135(7):1295-1302. doi: 10.1242/dev.016402
Europe PMC | doi