AAV-mediated genomic engineering

  • Develop novel ways to use viruses to genetically or epigenetically engineer somatic cells and the mouse germline, with or without CRISPR
  • Vector development to deliver CRISPR reagents including sgRNAs, HDR template and various Cas proteins
  • Improve targeting to desired cell type using known and/or novel serotypes

Genomic Engineering

  • Enhance the integration of large DNA repair templates via homology-directed repair (HDR)
  • Develop novel ways of delivery of HDR reagents to mouse embryos